Cargando…
COSMOS next generation – A public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals
The COSMOS Database (DB) was originally established to provide reliable data for cosmetics-related chemicals within the COSMOS Project funded as part of the SEURAT-1 Research Initiative. The database has subsequently been maintained and developed further into COSMOS Next Generation (NG), a combinati...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351204/ https://www.ncbi.nlm.nih.gov/pubmed/34405124 http://dx.doi.org/10.1016/j.comtox.2021.100175 |
_version_ | 1783735923514540032 |
---|---|
author | Yang, C. Cronin, M.T.D. Arvidson, K.B. Bienfait, B. Enoch, S.J. Heldreth, B. Hobocienski, B. Muldoon-Jacobs, K. Lan, Y. Madden, J.C. Magdziarz, T. Marusczyk, J. Mostrag, A. Nelms, M. Neagu, D. Przybylak, K. Rathman, J.F. Park, J. Richarz, A-N Richard, A.M. Ribeiro, J.V. Sacher, O. Schwab, C. Vitcheva, V. Volarath, P. Worth, A.P. |
author_facet | Yang, C. Cronin, M.T.D. Arvidson, K.B. Bienfait, B. Enoch, S.J. Heldreth, B. Hobocienski, B. Muldoon-Jacobs, K. Lan, Y. Madden, J.C. Magdziarz, T. Marusczyk, J. Mostrag, A. Nelms, M. Neagu, D. Przybylak, K. Rathman, J.F. Park, J. Richarz, A-N Richard, A.M. Ribeiro, J.V. Sacher, O. Schwab, C. Vitcheva, V. Volarath, P. Worth, A.P. |
author_sort | Yang, C. |
collection | PubMed |
description | The COSMOS Database (DB) was originally established to provide reliable data for cosmetics-related chemicals within the COSMOS Project funded as part of the SEURAT-1 Research Initiative. The database has subsequently been maintained and developed further into COSMOS Next Generation (NG), a combination of database and in silico tools, essential components of a knowledge base. COSMOS DB provided a cosmetics inventory as well as other regulatory inventories, accompanied by assessment results and in vitro and in vivo toxicity data. In addition to data content curation, much effort was dedicated to data governance – data authorisation, characterisation of quality, documentation of meta information, and control of data use. Through this effort, COSMOS DB was able to merge and fuse data of various types from different sources. Building on the previous effort, the COSMOS Minimum Inclusion (MINIS) criteria for a toxicity database were further expanded to quantify the reliability of studies. COSMOS NG features multiple fingerprints for analysing structure similarity, and new tools to calculate molecular properties and screen chemicals with endpoint-related public profilers, such as DNA and protein binders, liver alerts and genotoxic alerts. The publicly available COSMOS NG enables users to compile information and execute analyses such as category formation and read-across. This paper provides a step-by-step guided workflow for a simple read-across case, starting from a target structure and culminating in an estimation of a NOAEL confidence interval. Given its strong technical foundation, inclusion of quality-reviewed data, and provision of tools designed to facilitate communication between users, COSMOS NG is a first step towards building a toxicological knowledge hub leveraging many public data systems for chemical safety evaluation. We continue to monitor the feedback from the user community at support@mn-am.com. |
format | Online Article Text |
id | pubmed-8351204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier B.V |
record_format | MEDLINE/PubMed |
spelling | pubmed-83512042021-08-15 COSMOS next generation – A public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals Yang, C. Cronin, M.T.D. Arvidson, K.B. Bienfait, B. Enoch, S.J. Heldreth, B. Hobocienski, B. Muldoon-Jacobs, K. Lan, Y. Madden, J.C. Magdziarz, T. Marusczyk, J. Mostrag, A. Nelms, M. Neagu, D. Przybylak, K. Rathman, J.F. Park, J. Richarz, A-N Richard, A.M. Ribeiro, J.V. Sacher, O. Schwab, C. Vitcheva, V. Volarath, P. Worth, A.P. Comput Toxicol Article The COSMOS Database (DB) was originally established to provide reliable data for cosmetics-related chemicals within the COSMOS Project funded as part of the SEURAT-1 Research Initiative. The database has subsequently been maintained and developed further into COSMOS Next Generation (NG), a combination of database and in silico tools, essential components of a knowledge base. COSMOS DB provided a cosmetics inventory as well as other regulatory inventories, accompanied by assessment results and in vitro and in vivo toxicity data. In addition to data content curation, much effort was dedicated to data governance – data authorisation, characterisation of quality, documentation of meta information, and control of data use. Through this effort, COSMOS DB was able to merge and fuse data of various types from different sources. Building on the previous effort, the COSMOS Minimum Inclusion (MINIS) criteria for a toxicity database were further expanded to quantify the reliability of studies. COSMOS NG features multiple fingerprints for analysing structure similarity, and new tools to calculate molecular properties and screen chemicals with endpoint-related public profilers, such as DNA and protein binders, liver alerts and genotoxic alerts. The publicly available COSMOS NG enables users to compile information and execute analyses such as category formation and read-across. This paper provides a step-by-step guided workflow for a simple read-across case, starting from a target structure and culminating in an estimation of a NOAEL confidence interval. Given its strong technical foundation, inclusion of quality-reviewed data, and provision of tools designed to facilitate communication between users, COSMOS NG is a first step towards building a toxicological knowledge hub leveraging many public data systems for chemical safety evaluation. We continue to monitor the feedback from the user community at support@mn-am.com. Elsevier B.V 2021-08 /pmc/articles/PMC8351204/ /pubmed/34405124 http://dx.doi.org/10.1016/j.comtox.2021.100175 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yang, C. Cronin, M.T.D. Arvidson, K.B. Bienfait, B. Enoch, S.J. Heldreth, B. Hobocienski, B. Muldoon-Jacobs, K. Lan, Y. Madden, J.C. Magdziarz, T. Marusczyk, J. Mostrag, A. Nelms, M. Neagu, D. Przybylak, K. Rathman, J.F. Park, J. Richarz, A-N Richard, A.M. Ribeiro, J.V. Sacher, O. Schwab, C. Vitcheva, V. Volarath, P. Worth, A.P. COSMOS next generation – A public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals |
title | COSMOS next generation – A public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals |
title_full | COSMOS next generation – A public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals |
title_fullStr | COSMOS next generation – A public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals |
title_full_unstemmed | COSMOS next generation – A public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals |
title_short | COSMOS next generation – A public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals |
title_sort | cosmos next generation – a public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351204/ https://www.ncbi.nlm.nih.gov/pubmed/34405124 http://dx.doi.org/10.1016/j.comtox.2021.100175 |
work_keys_str_mv | AT yangc cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT croninmtd cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT arvidsonkb cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT bienfaitb cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT enochsj cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT heldrethb cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT hobocienskib cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT muldoonjacobsk cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT lany cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT maddenjc cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT magdziarzt cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT marusczykj cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT mostraga cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT nelmsm cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT neagud cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT przybylakk cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT rathmanjf cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT parkj cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT richarzan cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT richardam cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT ribeirojv cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT sachero cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT schwabc cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT vitchevav cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT volarathp cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals AT worthap cosmosnextgenerationapublicknowledgebaseleveragingchemicalandbiologicaldatatosupporttheregulatoryassessmentofchemicals |