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Sarcoidosis and neuromyelitis optica in a patient with optic neuritis – a case report

We present a case of atypical recurrent optic neuritis. A man in his 50s presented with right optic neuritis and profound visual loss, associated with elevated inflammatory markers. Lymph‐node biopsy was consistent with sarcoidosis. Aquaporin‐4 antibodies were also present. Three months following co...

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Autores principales: Foster, Michael A., Collorone, Sara, Palace, Jacqueline, Acheson, James, Toosy, Ahmed T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351381/
https://www.ncbi.nlm.nih.gov/pubmed/34166585
http://dx.doi.org/10.1002/acn3.51413
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author Foster, Michael A.
Collorone, Sara
Palace, Jacqueline
Acheson, James
Toosy, Ahmed T.
author_facet Foster, Michael A.
Collorone, Sara
Palace, Jacqueline
Acheson, James
Toosy, Ahmed T.
author_sort Foster, Michael A.
collection PubMed
description We present a case of atypical recurrent optic neuritis. A man in his 50s presented with right optic neuritis and profound visual loss, associated with elevated inflammatory markers. Lymph‐node biopsy was consistent with sarcoidosis. Aquaporin‐4 antibodies were also present. Three months following corticosteroid treatment, his right optic neuritis relapsed, again with raised inflammatory markers. He was started on azathioprine and prednisolone with good effect. A dual diagnosis of sarcoidosis and neuromyelitis optica with aquaporin‐4 antibodies is very rare. Long‐term immunosuppression is required. The case highlights the importance of identifying the features and cause of atypical optic neuritis.
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spelling pubmed-83513812021-08-15 Sarcoidosis and neuromyelitis optica in a patient with optic neuritis – a case report Foster, Michael A. Collorone, Sara Palace, Jacqueline Acheson, James Toosy, Ahmed T. Ann Clin Transl Neurol Case Study We present a case of atypical recurrent optic neuritis. A man in his 50s presented with right optic neuritis and profound visual loss, associated with elevated inflammatory markers. Lymph‐node biopsy was consistent with sarcoidosis. Aquaporin‐4 antibodies were also present. Three months following corticosteroid treatment, his right optic neuritis relapsed, again with raised inflammatory markers. He was started on azathioprine and prednisolone with good effect. A dual diagnosis of sarcoidosis and neuromyelitis optica with aquaporin‐4 antibodies is very rare. Long‐term immunosuppression is required. The case highlights the importance of identifying the features and cause of atypical optic neuritis. John Wiley and Sons Inc. 2021-06-24 /pmc/articles/PMC8351381/ /pubmed/34166585 http://dx.doi.org/10.1002/acn3.51413 Text en © 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Study
Foster, Michael A.
Collorone, Sara
Palace, Jacqueline
Acheson, James
Toosy, Ahmed T.
Sarcoidosis and neuromyelitis optica in a patient with optic neuritis – a case report
title Sarcoidosis and neuromyelitis optica in a patient with optic neuritis – a case report
title_full Sarcoidosis and neuromyelitis optica in a patient with optic neuritis – a case report
title_fullStr Sarcoidosis and neuromyelitis optica in a patient with optic neuritis – a case report
title_full_unstemmed Sarcoidosis and neuromyelitis optica in a patient with optic neuritis – a case report
title_short Sarcoidosis and neuromyelitis optica in a patient with optic neuritis – a case report
title_sort sarcoidosis and neuromyelitis optica in a patient with optic neuritis – a case report
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351381/
https://www.ncbi.nlm.nih.gov/pubmed/34166585
http://dx.doi.org/10.1002/acn3.51413
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