DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, with a pooled‐analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid‐19 severity was assessed by multivariate ordinal‐logistic models and pooled by a fixed‐effect m...

Descripción completa

Detalles Bibliográficos
Autores principales: Sormani, Maria Pia, Salvetti, Marco, Labauge, Pierre, Schiavetti, Irene, Zephir, Helene, Carmisciano, Luca, Bensa, Caroline, De Rossi, Nicola, Pelletier, Jean, Cordioli, Cinzia, Vukusic, Sandra, Moiola, Lucia, Kerschen, Philippe, Radaelli, Marta, Théaudin, Marie, Immovilli, Paolo, Casez, Olivier, Capobianco, Marco, Ciron, Jonathan, Trojano, Maria, Stankoff, Bruno, Créange, Alain, Tedeschi, Gioacchino, Clavelou, Pierre, Comi, Giancarlo, Thouvenot, Eric, Battaglia, Mario Alberto, Moreau, Thibault, Patti, Francesco, De Sèze, Jérôme, Louapre, Celine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351392/
https://www.ncbi.nlm.nih.gov/pubmed/34240579
http://dx.doi.org/10.1002/acn3.51408
Descripción
Sumario:We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, with a pooled‐analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid‐19 severity was assessed by multivariate ordinal‐logistic models and pooled by a fixed‐effect meta‐analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti‐CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid‐19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled‐analysis confirms an increased risk of severe Covid‐19 in patients on anti‐CD20 therapies and supports the protective role of interferon.

Ejemplares similares