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DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France
We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, with a pooled‐analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid‐19 severity was assessed by multivariate ordinal‐logistic models and pooled by a fixed‐effect m...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351392/ https://www.ncbi.nlm.nih.gov/pubmed/34240579 http://dx.doi.org/10.1002/acn3.51408 |
| _version_ | 1783735965216407552 |
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| author | Sormani, Maria Pia Salvetti, Marco Labauge, Pierre Schiavetti, Irene Zephir, Helene Carmisciano, Luca Bensa, Caroline De Rossi, Nicola Pelletier, Jean Cordioli, Cinzia Vukusic, Sandra Moiola, Lucia Kerschen, Philippe Radaelli, Marta Théaudin, Marie Immovilli, Paolo Casez, Olivier Capobianco, Marco Ciron, Jonathan Trojano, Maria Stankoff, Bruno Créange, Alain Tedeschi, Gioacchino Clavelou, Pierre Comi, Giancarlo Thouvenot, Eric Battaglia, Mario Alberto Moreau, Thibault Patti, Francesco De Sèze, Jérôme Louapre, Celine |
| author_facet | Sormani, Maria Pia Salvetti, Marco Labauge, Pierre Schiavetti, Irene Zephir, Helene Carmisciano, Luca Bensa, Caroline De Rossi, Nicola Pelletier, Jean Cordioli, Cinzia Vukusic, Sandra Moiola, Lucia Kerschen, Philippe Radaelli, Marta Théaudin, Marie Immovilli, Paolo Casez, Olivier Capobianco, Marco Ciron, Jonathan Trojano, Maria Stankoff, Bruno Créange, Alain Tedeschi, Gioacchino Clavelou, Pierre Comi, Giancarlo Thouvenot, Eric Battaglia, Mario Alberto Moreau, Thibault Patti, Francesco De Sèze, Jérôme Louapre, Celine |
| author_sort | Sormani, Maria Pia |
| collection | PubMed |
| description | We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, with a pooled‐analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid‐19 severity was assessed by multivariate ordinal‐logistic models and pooled by a fixed‐effect meta‐analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti‐CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid‐19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled‐analysis confirms an increased risk of severe Covid‐19 in patients on anti‐CD20 therapies and supports the protective role of interferon. |
| format | Online Article Text |
| id | pubmed-8351392 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-83513922021-08-15 DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France Sormani, Maria Pia Salvetti, Marco Labauge, Pierre Schiavetti, Irene Zephir, Helene Carmisciano, Luca Bensa, Caroline De Rossi, Nicola Pelletier, Jean Cordioli, Cinzia Vukusic, Sandra Moiola, Lucia Kerschen, Philippe Radaelli, Marta Théaudin, Marie Immovilli, Paolo Casez, Olivier Capobianco, Marco Ciron, Jonathan Trojano, Maria Stankoff, Bruno Créange, Alain Tedeschi, Gioacchino Clavelou, Pierre Comi, Giancarlo Thouvenot, Eric Battaglia, Mario Alberto Moreau, Thibault Patti, Francesco De Sèze, Jérôme Louapre, Celine Ann Clin Transl Neurol Brief Communications We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, with a pooled‐analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid‐19 severity was assessed by multivariate ordinal‐logistic models and pooled by a fixed‐effect meta‐analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti‐CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid‐19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled‐analysis confirms an increased risk of severe Covid‐19 in patients on anti‐CD20 therapies and supports the protective role of interferon. John Wiley and Sons Inc. 2021-07-07 /pmc/articles/PMC8351392/ /pubmed/34240579 http://dx.doi.org/10.1002/acn3.51408 Text en © 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Brief Communications Sormani, Maria Pia Salvetti, Marco Labauge, Pierre Schiavetti, Irene Zephir, Helene Carmisciano, Luca Bensa, Caroline De Rossi, Nicola Pelletier, Jean Cordioli, Cinzia Vukusic, Sandra Moiola, Lucia Kerschen, Philippe Radaelli, Marta Théaudin, Marie Immovilli, Paolo Casez, Olivier Capobianco, Marco Ciron, Jonathan Trojano, Maria Stankoff, Bruno Créange, Alain Tedeschi, Gioacchino Clavelou, Pierre Comi, Giancarlo Thouvenot, Eric Battaglia, Mario Alberto Moreau, Thibault Patti, Francesco De Sèze, Jérôme Louapre, Celine DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France |
| title | DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France |
| title_full | DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France |
| title_fullStr | DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France |
| title_full_unstemmed | DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France |
| title_short | DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France |
| title_sort | dmts and covid‐19 severity in ms: a pooled analysis from italy and france |
| topic | Brief Communications |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351392/ https://www.ncbi.nlm.nih.gov/pubmed/34240579 http://dx.doi.org/10.1002/acn3.51408 |
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