Evaluation of peripherin in biofluids of patients with motor neuron diseases

Peripherin (PRPH), a type III intermediate filament, assembles with neurofilaments in neurons of the peripheral nervous system, including lower motor neurons (LMN). To evaluate the role of PRPH in LMN degeneration, we assessed PRPH and neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and...

Descripción completa

Detalles Bibliográficos
Autores principales: Sabbatini, Daniele, Raggi, Flavia, Ruggero, Susanna, Seguso, Mara, Mandrioli, Jessica, Cagnin, Annachiara, Briani, Chiara, Toffanin, Elisabetta, Gizzi, Matteo, Fortuna, Andrea, Bello, Luca, Pegoraro, Elena, Musso, Giulia, Sorarù, Gianni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351396/
https://www.ncbi.nlm.nih.gov/pubmed/34264016
http://dx.doi.org/10.1002/acn3.51419
_version_ 1783735966248206336
author Sabbatini, Daniele
Raggi, Flavia
Ruggero, Susanna
Seguso, Mara
Mandrioli, Jessica
Cagnin, Annachiara
Briani, Chiara
Toffanin, Elisabetta
Gizzi, Matteo
Fortuna, Andrea
Bello, Luca
Pegoraro, Elena
Musso, Giulia
Sorarù, Gianni
author_facet Sabbatini, Daniele
Raggi, Flavia
Ruggero, Susanna
Seguso, Mara
Mandrioli, Jessica
Cagnin, Annachiara
Briani, Chiara
Toffanin, Elisabetta
Gizzi, Matteo
Fortuna, Andrea
Bello, Luca
Pegoraro, Elena
Musso, Giulia
Sorarù, Gianni
author_sort Sabbatini, Daniele
collection PubMed
description Peripherin (PRPH), a type III intermediate filament, assembles with neurofilaments in neurons of the peripheral nervous system, including lower motor neurons (LMN). To evaluate the role of PRPH in LMN degeneration, we assessed PRPH and neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and serum of 91 patients with motor neuron diseases (MND) and 69 controls. Overall, we found PRPH to be more concentrated in serum than in CSF. Serum PRPH resulted significantly increased in MND patients but it was unrelated to CSF‐NfL or survival in the amyotrophic lateral sclerosis (ALS) subset. PRPH might represent a marker of LMN involvement.
format Online
Article
Text
id pubmed-8351396
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-83513962021-08-15 Evaluation of peripherin in biofluids of patients with motor neuron diseases Sabbatini, Daniele Raggi, Flavia Ruggero, Susanna Seguso, Mara Mandrioli, Jessica Cagnin, Annachiara Briani, Chiara Toffanin, Elisabetta Gizzi, Matteo Fortuna, Andrea Bello, Luca Pegoraro, Elena Musso, Giulia Sorarù, Gianni Ann Clin Transl Neurol Brief Communications Peripherin (PRPH), a type III intermediate filament, assembles with neurofilaments in neurons of the peripheral nervous system, including lower motor neurons (LMN). To evaluate the role of PRPH in LMN degeneration, we assessed PRPH and neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and serum of 91 patients with motor neuron diseases (MND) and 69 controls. Overall, we found PRPH to be more concentrated in serum than in CSF. Serum PRPH resulted significantly increased in MND patients but it was unrelated to CSF‐NfL or survival in the amyotrophic lateral sclerosis (ALS) subset. PRPH might represent a marker of LMN involvement. John Wiley and Sons Inc. 2021-07-15 /pmc/articles/PMC8351396/ /pubmed/34264016 http://dx.doi.org/10.1002/acn3.51419 Text en © 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Sabbatini, Daniele
Raggi, Flavia
Ruggero, Susanna
Seguso, Mara
Mandrioli, Jessica
Cagnin, Annachiara
Briani, Chiara
Toffanin, Elisabetta
Gizzi, Matteo
Fortuna, Andrea
Bello, Luca
Pegoraro, Elena
Musso, Giulia
Sorarù, Gianni
Evaluation of peripherin in biofluids of patients with motor neuron diseases
title Evaluation of peripherin in biofluids of patients with motor neuron diseases
title_full Evaluation of peripherin in biofluids of patients with motor neuron diseases
title_fullStr Evaluation of peripherin in biofluids of patients with motor neuron diseases
title_full_unstemmed Evaluation of peripherin in biofluids of patients with motor neuron diseases
title_short Evaluation of peripherin in biofluids of patients with motor neuron diseases
title_sort evaluation of peripherin in biofluids of patients with motor neuron diseases
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351396/
https://www.ncbi.nlm.nih.gov/pubmed/34264016
http://dx.doi.org/10.1002/acn3.51419
work_keys_str_mv AT sabbatinidaniele evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases
AT raggiflavia evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases
AT ruggerosusanna evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases
AT segusomara evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases
AT mandriolijessica evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases
AT cagninannachiara evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases
AT brianichiara evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases
AT toffaninelisabetta evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases
AT gizzimatteo evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases
AT fortunaandrea evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases
AT belloluca evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases
AT pegoraroelena evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases
AT mussogiulia evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases
AT sorarugianni evaluationofperipherininbiofluidsofpatientswithmotorneurondiseases

Ejemplares similares