Longitudinal change in TSPO PET imaging in progressive multiple sclerosis

The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC withi...

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Detalles Bibliográficos
Autores principales: Kang, Yeona, Pandya, Sneha, Zinger, Nicole, Michaelson, Nara, Gauthier, Susan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351399/
https://www.ncbi.nlm.nih.gov/pubmed/34310086
http://dx.doi.org/10.1002/acn3.51431
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author Kang, Yeona
Pandya, Sneha
Zinger, Nicole
Michaelson, Nara
Gauthier, Susan A.
author_facet Kang, Yeona
Pandya, Sneha
Zinger, Nicole
Michaelson, Nara
Gauthier, Susan A.
author_sort Kang, Yeona
collection PubMed
description The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal‐appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM (p = 0.01), cortex (p = 0.04), thalamus (p = 0.04), and putamen (p = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195. Our data suggest that innate immune activity may increase over time in patients with progressive MS.
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spelling pubmed-83513992021-08-15 Longitudinal change in TSPO PET imaging in progressive multiple sclerosis Kang, Yeona Pandya, Sneha Zinger, Nicole Michaelson, Nara Gauthier, Susan A. Ann Clin Transl Neurol Short Communication The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal‐appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM (p = 0.01), cortex (p = 0.04), thalamus (p = 0.04), and putamen (p = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195. Our data suggest that innate immune activity may increase over time in patients with progressive MS. John Wiley and Sons Inc. 2021-07-26 /pmc/articles/PMC8351399/ /pubmed/34310086 http://dx.doi.org/10.1002/acn3.51431 Text en © 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Short Communication
Kang, Yeona
Pandya, Sneha
Zinger, Nicole
Michaelson, Nara
Gauthier, Susan A.
Longitudinal change in TSPO PET imaging in progressive multiple sclerosis
title Longitudinal change in TSPO PET imaging in progressive multiple sclerosis
title_full Longitudinal change in TSPO PET imaging in progressive multiple sclerosis
title_fullStr Longitudinal change in TSPO PET imaging in progressive multiple sclerosis
title_full_unstemmed Longitudinal change in TSPO PET imaging in progressive multiple sclerosis
title_short Longitudinal change in TSPO PET imaging in progressive multiple sclerosis
title_sort longitudinal change in tspo pet imaging in progressive multiple sclerosis
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351399/
https://www.ncbi.nlm.nih.gov/pubmed/34310086
http://dx.doi.org/10.1002/acn3.51431
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AT michaelsonnara longitudinalchangeintspopetimaginginprogressivemultiplesclerosis
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