MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can give ris...

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Autores principales: Ahmadi, Seyed Esmaeil, Rahimi, Samira, Zarandi, Bahman, Chegeni, Rouzbeh, Safa, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351444/
https://www.ncbi.nlm.nih.gov/pubmed/34372899
http://dx.doi.org/10.1186/s13045-021-01111-4
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author Ahmadi, Seyed Esmaeil
Rahimi, Samira
Zarandi, Bahman
Chegeni, Rouzbeh
Safa, Majid
author_facet Ahmadi, Seyed Esmaeil
Rahimi, Samira
Zarandi, Bahman
Chegeni, Rouzbeh
Safa, Majid
author_sort Ahmadi, Seyed Esmaeil
collection PubMed
description MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can give rise to a variety of cancers. In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be beneficial for treating hematologic malignancies.
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spelling pubmed-83514442021-08-10 MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies Ahmadi, Seyed Esmaeil Rahimi, Samira Zarandi, Bahman Chegeni, Rouzbeh Safa, Majid J Hematol Oncol Review MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can give rise to a variety of cancers. In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be beneficial for treating hematologic malignancies. BioMed Central 2021-08-09 /pmc/articles/PMC8351444/ /pubmed/34372899 http://dx.doi.org/10.1186/s13045-021-01111-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ahmadi, Seyed Esmaeil
Rahimi, Samira
Zarandi, Bahman
Chegeni, Rouzbeh
Safa, Majid
MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
title MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
title_full MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
title_fullStr MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
title_full_unstemmed MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
title_short MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
title_sort myc: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351444/
https://www.ncbi.nlm.nih.gov/pubmed/34372899
http://dx.doi.org/10.1186/s13045-021-01111-4
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