Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice

BACKGROUND: To examine the effects of BI 1029539 (GS-248), a novel selective human microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, in experimental models of acute lung injury (ALI) and sepsis in transgenic mice constitutively expressing the mPGES1 (Ptges) humanized allele. METHODS: Series...

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Detalles Bibliográficos
Autores principales: Gurusamy, Malarvizhi, Nasseri, Saeed, Rampa, Dileep Reddy, Feng, Huiying, Lee, Dongwon, Pekcec, Anton, Doods, Henri, Wu, Dongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351447/
https://www.ncbi.nlm.nih.gov/pubmed/34372885
http://dx.doi.org/10.1186/s12967-021-03016-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351447/
https://www.ncbi.nlm.nih.gov/pubmed/34372885
http://dx.doi.org/10.1186/s12967-021-03016-9

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