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The relationship between epicardial fat thickness and high-grade varicocele

BACKGROUND: Varicocele is abnormal dilation of testis veins. The precise mechanism of varicocele is not fully understood despite some hypothesis were suggested in the literature. Disequilibrium between constrictor and dilatator mechanism of the veins have been shown to cause varicocele. High-grade v...

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Autores principales: Sincer, Isa, Erdal, Emrah, Gucuk, Adnan, Bostancı, Emre, Gunes, Yilmaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351843/
https://www.ncbi.nlm.nih.gov/pubmed/34394236
http://dx.doi.org/10.4314/ahs.v20i4.28
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author Sincer, Isa
Erdal, Emrah
Gucuk, Adnan
Bostancı, Emre
Gunes, Yilmaz
author_facet Sincer, Isa
Erdal, Emrah
Gucuk, Adnan
Bostancı, Emre
Gunes, Yilmaz
author_sort Sincer, Isa
collection PubMed
description BACKGROUND: Varicocele is abnormal dilation of testis veins. The precise mechanism of varicocele is not fully understood despite some hypothesis were suggested in the literature. Disequilibrium between constrictor and dilatator mechanism of the veins have been shown to cause varicocele. High-grade varicoceles have been also linked to endothelial dysfunction and increased vasoconstriction. OBJECTIVES: We hypothesized that epicardial fat thickness (EFT), flow-mediated dilatation (FMD) and aortic stiffness (AS) could be associated with varicocele. In the present study, we aimed to compare vascular parameters such as FMD, EFT and AS in healthy subjects and high-grade varicocele patients. METHODS: The study population consisted of 35 men with high-grade varicocele and 32 age- and sex-matched control subjects younger than 45 years old. This is a cross-sectional study conducted at Bolu Abant Izzet Baysal University Hospital between May to October 2018. RESULTS: EFT, aortic diastolic diameters (AoDD) and EFT/BMI ratio were significantly higher in control group than in patients with high-grade (p=0.012, p=0.044, p=0.026, respectively). EFT and EFT /BMI ratio were significantly and inversely correlated with presence of varicocele (r=-0.422, p=0.009; r=-0.38, p=0.026, respectively). CONCLUSION: The present study suggests that high-grade varicocele may be associated with decreased echocardiographic EFT but not with aortic stiffness and FMD.
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spelling pubmed-83518432021-08-12 The relationship between epicardial fat thickness and high-grade varicocele Sincer, Isa Erdal, Emrah Gucuk, Adnan Bostancı, Emre Gunes, Yilmaz Afr Health Sci Articles BACKGROUND: Varicocele is abnormal dilation of testis veins. The precise mechanism of varicocele is not fully understood despite some hypothesis were suggested in the literature. Disequilibrium between constrictor and dilatator mechanism of the veins have been shown to cause varicocele. High-grade varicoceles have been also linked to endothelial dysfunction and increased vasoconstriction. OBJECTIVES: We hypothesized that epicardial fat thickness (EFT), flow-mediated dilatation (FMD) and aortic stiffness (AS) could be associated with varicocele. In the present study, we aimed to compare vascular parameters such as FMD, EFT and AS in healthy subjects and high-grade varicocele patients. METHODS: The study population consisted of 35 men with high-grade varicocele and 32 age- and sex-matched control subjects younger than 45 years old. This is a cross-sectional study conducted at Bolu Abant Izzet Baysal University Hospital between May to October 2018. RESULTS: EFT, aortic diastolic diameters (AoDD) and EFT/BMI ratio were significantly higher in control group than in patients with high-grade (p=0.012, p=0.044, p=0.026, respectively). EFT and EFT /BMI ratio were significantly and inversely correlated with presence of varicocele (r=-0.422, p=0.009; r=-0.38, p=0.026, respectively). CONCLUSION: The present study suggests that high-grade varicocele may be associated with decreased echocardiographic EFT but not with aortic stiffness and FMD. Makerere Medical School 2020-12 /pmc/articles/PMC8351843/ /pubmed/34394236 http://dx.doi.org/10.4314/ahs.v20i4.28 Text en © 2020 Sincer I et al. https://creativecommons.org/licenses/by/4.0/Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Sincer, Isa
Erdal, Emrah
Gucuk, Adnan
Bostancı, Emre
Gunes, Yilmaz
The relationship between epicardial fat thickness and high-grade varicocele
title The relationship between epicardial fat thickness and high-grade varicocele
title_full The relationship between epicardial fat thickness and high-grade varicocele
title_fullStr The relationship between epicardial fat thickness and high-grade varicocele
title_full_unstemmed The relationship between epicardial fat thickness and high-grade varicocele
title_short The relationship between epicardial fat thickness and high-grade varicocele
title_sort relationship between epicardial fat thickness and high-grade varicocele
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351843/
https://www.ncbi.nlm.nih.gov/pubmed/34394236
http://dx.doi.org/10.4314/ahs.v20i4.28
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