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Non- pancreatic neuroendocrine tumour presenting with hypoglycemia in an elderly patient

BACKGROUND: Hypoglycemia is a common, symptom seen in individuals. Hypoglycemia in the elderly is both under-recognized and misdiagnosed due to nonspesific hypoglycemic symptoms and accompanying comorbidities in this population. In diabetic individuals, hypoglycemia is most commonly caused by admini...

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Autores principales: Eren, Merve, Bostan, Feyzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351849/
https://www.ncbi.nlm.nih.gov/pubmed/34394252
http://dx.doi.org/10.4314/ahs.v20i4.44
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author Eren, Merve
Bostan, Feyzi
author_facet Eren, Merve
Bostan, Feyzi
author_sort Eren, Merve
collection PubMed
description BACKGROUND: Hypoglycemia is a common, symptom seen in individuals. Hypoglycemia in the elderly is both under-recognized and misdiagnosed due to nonspesific hypoglycemic symptoms and accompanying comorbidities in this population. In diabetic individuals, hypoglycemia is most commonly caused by administering insulin or sulphonylureas and insulin secretagogues. Other drugs, such as antibiotics or beta-blockers, have been reported to reduce blood glucose to abnormally low levels. Hypoglycemia in non-diabetic patients is considered a rare event, and the possible reasons may be reactive hypoglycemia, insulin-secreting tumours and other malignancies, hypopituitarism, hypocortisolism, alcohol abuse, inappropriate insulin self-administration, malnutrition, renal failure and sepsis. CASE: An 86- year- old male was admitted to the emergency department with hypoglycemia diagnosed with non-pancreatic neuroendocrine tumour (NET) on lung secreting insulin. No surgical intervention or chemotherapy was planned due to patients age and comorbidities so best supportive care was planned. We used prednisone for symptomatic treatment of hypoglycemia and the patient has been followed up periodically. In this period he had no hypoglycemic attack. CONCLUSION: For patients with hypoglycemia who are unable/decline to receive any further treatment, low dose glucocorticoid is a good choice to achieve normoglycemia. It seems to be more cost effective compared to other treatment options. Furthermore hospitalisation rates may decrease due to decreased hypogylcemic attacks.
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spelling pubmed-83518492021-08-12 Non- pancreatic neuroendocrine tumour presenting with hypoglycemia in an elderly patient Eren, Merve Bostan, Feyzi Afr Health Sci Articles BACKGROUND: Hypoglycemia is a common, symptom seen in individuals. Hypoglycemia in the elderly is both under-recognized and misdiagnosed due to nonspesific hypoglycemic symptoms and accompanying comorbidities in this population. In diabetic individuals, hypoglycemia is most commonly caused by administering insulin or sulphonylureas and insulin secretagogues. Other drugs, such as antibiotics or beta-blockers, have been reported to reduce blood glucose to abnormally low levels. Hypoglycemia in non-diabetic patients is considered a rare event, and the possible reasons may be reactive hypoglycemia, insulin-secreting tumours and other malignancies, hypopituitarism, hypocortisolism, alcohol abuse, inappropriate insulin self-administration, malnutrition, renal failure and sepsis. CASE: An 86- year- old male was admitted to the emergency department with hypoglycemia diagnosed with non-pancreatic neuroendocrine tumour (NET) on lung secreting insulin. No surgical intervention or chemotherapy was planned due to patients age and comorbidities so best supportive care was planned. We used prednisone for symptomatic treatment of hypoglycemia and the patient has been followed up periodically. In this period he had no hypoglycemic attack. CONCLUSION: For patients with hypoglycemia who are unable/decline to receive any further treatment, low dose glucocorticoid is a good choice to achieve normoglycemia. It seems to be more cost effective compared to other treatment options. Furthermore hospitalisation rates may decrease due to decreased hypogylcemic attacks. Makerere Medical School 2020-12 /pmc/articles/PMC8351849/ /pubmed/34394252 http://dx.doi.org/10.4314/ahs.v20i4.44 Text en © 2020 Eren M et al. https://creativecommons.org/licenses/by/4.0/Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Eren, Merve
Bostan, Feyzi
Non- pancreatic neuroendocrine tumour presenting with hypoglycemia in an elderly patient
title Non- pancreatic neuroendocrine tumour presenting with hypoglycemia in an elderly patient
title_full Non- pancreatic neuroendocrine tumour presenting with hypoglycemia in an elderly patient
title_fullStr Non- pancreatic neuroendocrine tumour presenting with hypoglycemia in an elderly patient
title_full_unstemmed Non- pancreatic neuroendocrine tumour presenting with hypoglycemia in an elderly patient
title_short Non- pancreatic neuroendocrine tumour presenting with hypoglycemia in an elderly patient
title_sort non- pancreatic neuroendocrine tumour presenting with hypoglycemia in an elderly patient
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351849/
https://www.ncbi.nlm.nih.gov/pubmed/34394252
http://dx.doi.org/10.4314/ahs.v20i4.44
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