Nras(Q61R/+) and Kras(−/−) cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors

Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is an aggressive subtype of T-cell ALL. Although genetic mutations hyperactivating cytokine receptor/Ras signaling are prevalent in ETP-ALL, it remains unknown how activated Ras signaling contributes to ETP-ALL. Here, we find that in addi...

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Detalles Bibliográficos
Autores principales: Wen, Zhi, Yun, Grant, Hebert, Alexander, Kong, Guangyao, Ranheim, Erik A., Finn, Remington, Rajagoplan, Adhithi, Li, Shuyi, Zhou, Yun, Yu, Mei, Damnernsawad, Alisa, Roose, Jeroen P., Coon, Joshua J., Wen, Renren, Wang, Demin, Zhang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351901/
https://www.ncbi.nlm.nih.gov/pubmed/33512434
http://dx.doi.org/10.1182/blood.2020009082

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