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New insight into the role of MDMX in MDM2-mediated p53 degradation and anti-cancer drug development
Inactivation of the tumor suppressor p53 has been generally accepted as a hallmark of tumor. MDM2 and MDMX, the two closely related proteins are considered to be critical for negatively regulating p53 activity through inhibitory binding to and post-translational modification of the p53 protein. We h...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Impact Journals LLC
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351915/ https://www.ncbi.nlm.nih.gov/pubmed/34386548 http://dx.doi.org/10.18632/oncoscience.542 |