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Evaluation the relationship between psychological profile and salivary cortisol in patients with recurrent aphthous stomatitis
BACKGROUND: Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal diseases which are diagnosed with recurrent and painful ulcers. The possible association between psychological factors and salivary stress related factors in patients with aphthous ulcers has been discussed in var...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351933/ https://www.ncbi.nlm.nih.gov/pubmed/34429870 |
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author | Mirzaei, Marjan Zarabadipour, Mahdieh Mirzadeh, Monirsadat |
author_facet | Mirzaei, Marjan Zarabadipour, Mahdieh Mirzadeh, Monirsadat |
author_sort | Mirzaei, Marjan |
collection | PubMed |
description | BACKGROUND: Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal diseases which are diagnosed with recurrent and painful ulcers. The possible association between psychological factors and salivary stress related factors in patients with aphthous ulcers has been discussed in various studies. The aim of this study was to evaluate salivary cortisol level, anxiety, and depression in patients with RAS. MATERIALS AND METHODS: In this case control study, 30 patients with RAS and 30 healthy individuals were enrolled by matching their age and sex. Anxiety and depression were assessed by beck anxiety inventory and beck depression inventory. Unstimulated saliva of both groups were collected and then tested by DiaMetra kit and the ELISA method. Data were analyzed by SPSS using an Independent t-test and Mann–Whitney test. A statistical significance level of <0.05 was considered. RESULTS: The mean salivary cortisol in the case group was 5.35 ng/ml and in the control group was 4.73 ng/ml which was not statistically significant (P > 0.05). There was no significant difference in anxiety and depression level between the two groups (P > 0.05). According to Spearman correlation coefficient, there was an average, negative, and significant correlation between salivary cortisol and anxiety and depression scores in the case group (P < 0.05). CONCLUSION: This study shows that, although the mean salivary cortisol was slightly higher in patients with aphthous lesions, anxiety, and depression were not possible factors for RAS. There was a moderate, negative correlation between salivary cortisol level and stress and anxiety in patients with RAS. |
format | Online Article Text |
id | pubmed-8351933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-83519332021-08-23 Evaluation the relationship between psychological profile and salivary cortisol in patients with recurrent aphthous stomatitis Mirzaei, Marjan Zarabadipour, Mahdieh Mirzadeh, Monirsadat Dent Res J (Isfahan) Original Article BACKGROUND: Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal diseases which are diagnosed with recurrent and painful ulcers. The possible association between psychological factors and salivary stress related factors in patients with aphthous ulcers has been discussed in various studies. The aim of this study was to evaluate salivary cortisol level, anxiety, and depression in patients with RAS. MATERIALS AND METHODS: In this case control study, 30 patients with RAS and 30 healthy individuals were enrolled by matching their age and sex. Anxiety and depression were assessed by beck anxiety inventory and beck depression inventory. Unstimulated saliva of both groups were collected and then tested by DiaMetra kit and the ELISA method. Data were analyzed by SPSS using an Independent t-test and Mann–Whitney test. A statistical significance level of <0.05 was considered. RESULTS: The mean salivary cortisol in the case group was 5.35 ng/ml and in the control group was 4.73 ng/ml which was not statistically significant (P > 0.05). There was no significant difference in anxiety and depression level between the two groups (P > 0.05). According to Spearman correlation coefficient, there was an average, negative, and significant correlation between salivary cortisol and anxiety and depression scores in the case group (P < 0.05). CONCLUSION: This study shows that, although the mean salivary cortisol was slightly higher in patients with aphthous lesions, anxiety, and depression were not possible factors for RAS. There was a moderate, negative correlation between salivary cortisol level and stress and anxiety in patients with RAS. Wolters Kluwer - Medknow 2021-06-22 /pmc/articles/PMC8351933/ /pubmed/34429870 Text en Copyright: © 2021 Dental Research Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Mirzaei, Marjan Zarabadipour, Mahdieh Mirzadeh, Monirsadat Evaluation the relationship between psychological profile and salivary cortisol in patients with recurrent aphthous stomatitis |
title | Evaluation the relationship between psychological profile and salivary cortisol in patients with recurrent aphthous stomatitis |
title_full | Evaluation the relationship between psychological profile and salivary cortisol in patients with recurrent aphthous stomatitis |
title_fullStr | Evaluation the relationship between psychological profile and salivary cortisol in patients with recurrent aphthous stomatitis |
title_full_unstemmed | Evaluation the relationship between psychological profile and salivary cortisol in patients with recurrent aphthous stomatitis |
title_short | Evaluation the relationship between psychological profile and salivary cortisol in patients with recurrent aphthous stomatitis |
title_sort | evaluation the relationship between psychological profile and salivary cortisol in patients with recurrent aphthous stomatitis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351933/ https://www.ncbi.nlm.nih.gov/pubmed/34429870 |
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