Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs

Sensing and response to environmental cues, such as pH and chloride (Cl(−)), is critical in enabling Mycobacterium tuberculosis (Mtb) colonization of its host. Utilizing a fluorescent reporter Mtb strain in a chemical screen, we have identified compounds that dysregulate Mtb response to high Cl(−) l...

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Detalles Bibliográficos
Autores principales: Lavin, Richard C., Johnson, Calvin, Ahn, Yong-Mo, Kremiller, Kyle M., Sherwood, Matthew, Patel, Jimmy S., Pan, Yan, Russo, Riccardo, MacGilvary, Nathan J., Giacalone, David, Kevorkian, Yuzo L., Zimmerman, Matthew D., Glickman, J. Fraser, Freundlich, Joel S., Tan, Shumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Discovery Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351955/
https://www.ncbi.nlm.nih.gov/pubmed/34319985
http://dx.doi.org/10.1371/journal.pbio.3001355

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