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Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome
Evolutionary forces like Hill-Robertson interference and negative epistasis can lead to deleterious mutations being found on distinct haplotypes. However, the extent to which these forces depend on the selection and dominance coefficients of deleterious mutations and shape genome-wide patterns of li...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351996/ https://www.ncbi.nlm.nih.gov/pubmed/34319975 http://dx.doi.org/10.1371/journal.pgen.1009676 |