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Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs

Background: Myocardial efficiency should be maintained stable under light-to-moderate stress conditions, but ischemia puts the myocardium at risk for impaired functionality. Additionally, the measurement of such efficiency typically requires invasive heart catheterization and exposure to ionizing ra...

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Autores principales: Faragli, Alessandro, Alogna, Alessio, Lee, Chong Bin, Zhu, Miry, Ghorbani, Niky, Lo Muzio, Francesco Paolo, Schnackenburg, Bernhard, Stehning, Christian, Kuehne, Titus, Post, Heiner, Goubergrits, Leonid, Nagel, Eike, Pieske, Burkert, Kelle, Sebastian, Kelm, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352437/
https://www.ncbi.nlm.nih.gov/pubmed/34381823
http://dx.doi.org/10.3389/fcvm.2021.689255
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author Faragli, Alessandro
Alogna, Alessio
Lee, Chong Bin
Zhu, Miry
Ghorbani, Niky
Lo Muzio, Francesco Paolo
Schnackenburg, Bernhard
Stehning, Christian
Kuehne, Titus
Post, Heiner
Goubergrits, Leonid
Nagel, Eike
Pieske, Burkert
Kelle, Sebastian
Kelm, Marcus
author_facet Faragli, Alessandro
Alogna, Alessio
Lee, Chong Bin
Zhu, Miry
Ghorbani, Niky
Lo Muzio, Francesco Paolo
Schnackenburg, Bernhard
Stehning, Christian
Kuehne, Titus
Post, Heiner
Goubergrits, Leonid
Nagel, Eike
Pieske, Burkert
Kelle, Sebastian
Kelm, Marcus
author_sort Faragli, Alessandro
collection PubMed
description Background: Myocardial efficiency should be maintained stable under light-to-moderate stress conditions, but ischemia puts the myocardium at risk for impaired functionality. Additionally, the measurement of such efficiency typically requires invasive heart catheterization and exposure to ionizing radiation. In this work, we aimed to non-invasively assess myocardial power and the resulting efficiency during pharmacological stress testing and ischemia induction. Methods: In a cohort of n = 10 healthy Landrace pigs, dobutamine stress testing was performed, followed by verapamil-induced ischemia alongside cardiac magnetic resonance (CMR) imaging. External myocardial power, internal myocardial power, and myocardial efficiency were assessed non-invasively using geometrical and functional parameters from CMR volumetric as well as blood flow and pressure measurements. Results: External myocardial power significantly increased under dobutamine stress [2.3 (1.6–3.1) W/m(2) vs. 1.3 (1.1–1.6) W/m(2), p = 0.005] and significantly decreased under verapamil-induced ischemia [0.8 (0.5–0.9) W/m(2), p = 0.005]. Internal myocardial power [baseline: 5.9 (4.6–8.5) W/m(2)] was not affected by dobutamine [7.5 (6.9–9.0) W/m(2), p = 0.241] nor verapamil [5.8 (4.7–8.8) W/m(2), p = 0.878]. Myocardial efficiency did not change from baseline to dobutamine [21% (15–27) vs. 31% (20–44), p = 0.059] but decreased significantly during verapamil-induced ischemia [10% (8–13), p = 0.005]. Conclusion: In healthy Landrace pigs, dobutamine stress increased external myocardial power, whereas myocardial efficiency was maintained stable. On the contrary, verapamil-induced ischemia substantially decreased external myocardial power and myocardial efficiency. Non-invasive CMR was able to quantify these efficiency losses and might be useful for future clinical studies evaluating the effects of therapeutic interventions on myocardial energetics.
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spelling pubmed-83524372021-08-10 Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs Faragli, Alessandro Alogna, Alessio Lee, Chong Bin Zhu, Miry Ghorbani, Niky Lo Muzio, Francesco Paolo Schnackenburg, Bernhard Stehning, Christian Kuehne, Titus Post, Heiner Goubergrits, Leonid Nagel, Eike Pieske, Burkert Kelle, Sebastian Kelm, Marcus Front Cardiovasc Med Cardiovascular Medicine Background: Myocardial efficiency should be maintained stable under light-to-moderate stress conditions, but ischemia puts the myocardium at risk for impaired functionality. Additionally, the measurement of such efficiency typically requires invasive heart catheterization and exposure to ionizing radiation. In this work, we aimed to non-invasively assess myocardial power and the resulting efficiency during pharmacological stress testing and ischemia induction. Methods: In a cohort of n = 10 healthy Landrace pigs, dobutamine stress testing was performed, followed by verapamil-induced ischemia alongside cardiac magnetic resonance (CMR) imaging. External myocardial power, internal myocardial power, and myocardial efficiency were assessed non-invasively using geometrical and functional parameters from CMR volumetric as well as blood flow and pressure measurements. Results: External myocardial power significantly increased under dobutamine stress [2.3 (1.6–3.1) W/m(2) vs. 1.3 (1.1–1.6) W/m(2), p = 0.005] and significantly decreased under verapamil-induced ischemia [0.8 (0.5–0.9) W/m(2), p = 0.005]. Internal myocardial power [baseline: 5.9 (4.6–8.5) W/m(2)] was not affected by dobutamine [7.5 (6.9–9.0) W/m(2), p = 0.241] nor verapamil [5.8 (4.7–8.8) W/m(2), p = 0.878]. Myocardial efficiency did not change from baseline to dobutamine [21% (15–27) vs. 31% (20–44), p = 0.059] but decreased significantly during verapamil-induced ischemia [10% (8–13), p = 0.005]. Conclusion: In healthy Landrace pigs, dobutamine stress increased external myocardial power, whereas myocardial efficiency was maintained stable. On the contrary, verapamil-induced ischemia substantially decreased external myocardial power and myocardial efficiency. Non-invasive CMR was able to quantify these efficiency losses and might be useful for future clinical studies evaluating the effects of therapeutic interventions on myocardial energetics. Frontiers Media S.A. 2021-07-26 /pmc/articles/PMC8352437/ /pubmed/34381823 http://dx.doi.org/10.3389/fcvm.2021.689255 Text en Copyright © 2021 Faragli, Alogna, Lee, Zhu, Ghorbani, Lo Muzio, Schnackenburg, Stehning, Kuehne, Post, Goubergrits, Nagel, Pieske, Kelle and Kelm. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Faragli, Alessandro
Alogna, Alessio
Lee, Chong Bin
Zhu, Miry
Ghorbani, Niky
Lo Muzio, Francesco Paolo
Schnackenburg, Bernhard
Stehning, Christian
Kuehne, Titus
Post, Heiner
Goubergrits, Leonid
Nagel, Eike
Pieske, Burkert
Kelle, Sebastian
Kelm, Marcus
Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs
title Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs
title_full Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs
title_fullStr Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs
title_full_unstemmed Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs
title_short Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs
title_sort non-invasive cmr-based quantification of myocardial power and efficiency under stress and ischemic conditions in landrace pigs
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352437/
https://www.ncbi.nlm.nih.gov/pubmed/34381823
http://dx.doi.org/10.3389/fcvm.2021.689255
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