How subtle changes in 3D structure can create large changes in transcription

Animal genomes are organized into topologically associated domains (TADs). TADs are thought to contribute to gene regulation by facilitating enhancer-promoter (E-P) contacts within a TAD and preventing these contacts across TAD borders. However, the absolute difference in contact frequency across TA...

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Detalles Bibliográficos
Autores principales: Xiao, Jordan Yupeng, Hafner, Antonina, Boettiger, Alistair N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352591/
https://www.ncbi.nlm.nih.gov/pubmed/34240703
http://dx.doi.org/10.7554/eLife.64320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352591/
https://www.ncbi.nlm.nih.gov/pubmed/34240703
http://dx.doi.org/10.7554/eLife.64320

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