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Application of Stem Cell Therapy for ACL Graft Regeneration
Graft regeneration after anterior cruciate ligament (ACL) reconstruction surgery is a complex three-stage process, which usually takes a long duration and often results in fibrous scar tissue formation that exerts a detrimental impact on the patients' prognosis. Hence, as a regeneration techniq...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352687/ https://www.ncbi.nlm.nih.gov/pubmed/34381504 http://dx.doi.org/10.1155/2021/6641818 |
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author | Wang, Canlong Hu, Yejun Zhang, Shichen Ruan, Dengfeng Huang, Zizhan He, Peiwen Cai, Honglu Heng, Boon Chin Chen, Xiao Shen, Weiliang |
author_facet | Wang, Canlong Hu, Yejun Zhang, Shichen Ruan, Dengfeng Huang, Zizhan He, Peiwen Cai, Honglu Heng, Boon Chin Chen, Xiao Shen, Weiliang |
author_sort | Wang, Canlong |
collection | PubMed |
description | Graft regeneration after anterior cruciate ligament (ACL) reconstruction surgery is a complex three-stage process, which usually takes a long duration and often results in fibrous scar tissue formation that exerts a detrimental impact on the patients' prognosis. Hence, as a regeneration technique, stem cell transplantation has attracted increasing attention. Several different stem cell types have been utilized in animal experiments, and almost all of these have shown good capacity in improving tendon-bone regeneration. Various differentiation inducers have been widely applied together with stem cells to enhance specific lineage differentiation, such as recombinant gene transfection, growth factors, and biomaterials. Among the various different types of stem cells, bone marrow-derived mesenchymal stem cells (BMSCs) have been investigated the most, while ligament stem progenitor cells (LDSCs) have demonstrated the best potential in generating tendon/ligament lineage cells. In the clinic, 4 relevant completed trials have been reported, but only one trial with BMSCs showed improved outcomes, while 5 relevant trials are still in progress. This review describes the process of ACL graft regeneration after implantation and summarizes the current application of stem cells from bench to bedside, as well as discusses future perspectives in this field. |
format | Online Article Text |
id | pubmed-8352687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-83526872021-08-10 Application of Stem Cell Therapy for ACL Graft Regeneration Wang, Canlong Hu, Yejun Zhang, Shichen Ruan, Dengfeng Huang, Zizhan He, Peiwen Cai, Honglu Heng, Boon Chin Chen, Xiao Shen, Weiliang Stem Cells Int Review Article Graft regeneration after anterior cruciate ligament (ACL) reconstruction surgery is a complex three-stage process, which usually takes a long duration and often results in fibrous scar tissue formation that exerts a detrimental impact on the patients' prognosis. Hence, as a regeneration technique, stem cell transplantation has attracted increasing attention. Several different stem cell types have been utilized in animal experiments, and almost all of these have shown good capacity in improving tendon-bone regeneration. Various differentiation inducers have been widely applied together with stem cells to enhance specific lineage differentiation, such as recombinant gene transfection, growth factors, and biomaterials. Among the various different types of stem cells, bone marrow-derived mesenchymal stem cells (BMSCs) have been investigated the most, while ligament stem progenitor cells (LDSCs) have demonstrated the best potential in generating tendon/ligament lineage cells. In the clinic, 4 relevant completed trials have been reported, but only one trial with BMSCs showed improved outcomes, while 5 relevant trials are still in progress. This review describes the process of ACL graft regeneration after implantation and summarizes the current application of stem cells from bench to bedside, as well as discusses future perspectives in this field. Hindawi 2021-08-02 /pmc/articles/PMC8352687/ /pubmed/34381504 http://dx.doi.org/10.1155/2021/6641818 Text en Copyright © 2021 Canlong Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wang, Canlong Hu, Yejun Zhang, Shichen Ruan, Dengfeng Huang, Zizhan He, Peiwen Cai, Honglu Heng, Boon Chin Chen, Xiao Shen, Weiliang Application of Stem Cell Therapy for ACL Graft Regeneration |
title | Application of Stem Cell Therapy for ACL Graft Regeneration |
title_full | Application of Stem Cell Therapy for ACL Graft Regeneration |
title_fullStr | Application of Stem Cell Therapy for ACL Graft Regeneration |
title_full_unstemmed | Application of Stem Cell Therapy for ACL Graft Regeneration |
title_short | Application of Stem Cell Therapy for ACL Graft Regeneration |
title_sort | application of stem cell therapy for acl graft regeneration |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352687/ https://www.ncbi.nlm.nih.gov/pubmed/34381504 http://dx.doi.org/10.1155/2021/6641818 |
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