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Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes
OBJECTIVE: To investigate the microvasculature and structural characteristics of the eyes of myopic patients and their association with posterior staphyloma (PS). METHODS: This was a retrospective, case-control study comprising of 106 eyes from 72 individuals. Using 1:1 matching of axial length (AL)...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352845/ https://www.ncbi.nlm.nih.gov/pubmed/33404680 http://dx.doi.org/10.1007/s00417-020-05057-0 |
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author | Nie, Fen Ouyang, Junyi Tang, Wenquan Luo, Lijia Cao, Mengdan Zhang, Lurong Zhou, Dengming Liu, Ke Ma, Daijin Duan, Xuanchu |
author_facet | Nie, Fen Ouyang, Junyi Tang, Wenquan Luo, Lijia Cao, Mengdan Zhang, Lurong Zhou, Dengming Liu, Ke Ma, Daijin Duan, Xuanchu |
author_sort | Nie, Fen |
collection | PubMed |
description | OBJECTIVE: To investigate the microvasculature and structural characteristics of the eyes of myopic patients and their association with posterior staphyloma (PS). METHODS: This was a retrospective, case-control study comprising of 106 eyes from 72 individuals. Using 1:1 matching of axial length (AL) of their eyes, patients were allocated into a PS group or no posterior staphyloma (NPS) group. All patients were examined using ultra-widefield fundus imaging, optical coherence tomography angiography, and ocular biometry to acquire microvasculature and microstructure parameters. RESULTS: The anterior chamber depth (ACD) of the PS group was significantly different from that of the NPS group (3.56 mm vs 3.76 mm, P < 0.001), as was 1ens thickness (3.72 mm vs 3.57 mm, P = 0.005) and spherical equivalent (SE)(-10.11D vs -8.80D, P = 0.014). The PS group had reduced choriocapillaris flow, subfoveal choroidal thickness (SFCT), and a thinner retinal layer compared with the NPS group. No difference in retinal blood flow between the two groups was observed. The PS group exhibited a smaller disc area (15082.89 vs 17,043.32, P = 0.003) and angle α between temporal retinal arterial vascular arcades (113.29°vs 128.39°, P = 0.003), a larger disc tilt ratio (1.41 vs 1.24, P < 0.001) and parapapillary atrophy (PPA) area (13840.98 vs 8753.86, P = 0.020), compared with the NPS group. Multivariate regression analysis indicated that disc tilt ratio (P = 0.031) and SFCT (P = 0.015) were significant predictors of PS. In addition, PS (P = 0.049), AL (P = 0.003), corneal refractive power (P < 0.001), ACD (P = 0.022), relative lens position (P = 0.045), and disc area (P = 0.011) were significant predictors of SE. CONCLUSIONS: PS was found to be closely linked to a reduction in choriocapillaris perfusion and anatomical abnormalities including posterior and anterior segments. Furthermore, PS exacerbated the progression of myopia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00417-020-05057-0. |
format | Online Article Text |
id | pubmed-8352845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-83528452021-08-24 Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes Nie, Fen Ouyang, Junyi Tang, Wenquan Luo, Lijia Cao, Mengdan Zhang, Lurong Zhou, Dengming Liu, Ke Ma, Daijin Duan, Xuanchu Graefes Arch Clin Exp Ophthalmol Retinal Disorders OBJECTIVE: To investigate the microvasculature and structural characteristics of the eyes of myopic patients and their association with posterior staphyloma (PS). METHODS: This was a retrospective, case-control study comprising of 106 eyes from 72 individuals. Using 1:1 matching of axial length (AL) of their eyes, patients were allocated into a PS group or no posterior staphyloma (NPS) group. All patients were examined using ultra-widefield fundus imaging, optical coherence tomography angiography, and ocular biometry to acquire microvasculature and microstructure parameters. RESULTS: The anterior chamber depth (ACD) of the PS group was significantly different from that of the NPS group (3.56 mm vs 3.76 mm, P < 0.001), as was 1ens thickness (3.72 mm vs 3.57 mm, P = 0.005) and spherical equivalent (SE)(-10.11D vs -8.80D, P = 0.014). The PS group had reduced choriocapillaris flow, subfoveal choroidal thickness (SFCT), and a thinner retinal layer compared with the NPS group. No difference in retinal blood flow between the two groups was observed. The PS group exhibited a smaller disc area (15082.89 vs 17,043.32, P = 0.003) and angle α between temporal retinal arterial vascular arcades (113.29°vs 128.39°, P = 0.003), a larger disc tilt ratio (1.41 vs 1.24, P < 0.001) and parapapillary atrophy (PPA) area (13840.98 vs 8753.86, P = 0.020), compared with the NPS group. Multivariate regression analysis indicated that disc tilt ratio (P = 0.031) and SFCT (P = 0.015) were significant predictors of PS. In addition, PS (P = 0.049), AL (P = 0.003), corneal refractive power (P < 0.001), ACD (P = 0.022), relative lens position (P = 0.045), and disc area (P = 0.011) were significant predictors of SE. CONCLUSIONS: PS was found to be closely linked to a reduction in choriocapillaris perfusion and anatomical abnormalities including posterior and anterior segments. Furthermore, PS exacerbated the progression of myopia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00417-020-05057-0. Springer Berlin Heidelberg 2021-01-06 2021 /pmc/articles/PMC8352845/ /pubmed/33404680 http://dx.doi.org/10.1007/s00417-020-05057-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Retinal Disorders Nie, Fen Ouyang, Junyi Tang, Wenquan Luo, Lijia Cao, Mengdan Zhang, Lurong Zhou, Dengming Liu, Ke Ma, Daijin Duan, Xuanchu Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes |
title | Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes |
title_full | Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes |
title_fullStr | Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes |
title_full_unstemmed | Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes |
title_short | Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes |
title_sort | posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes |
topic | Retinal Disorders |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352845/ https://www.ncbi.nlm.nih.gov/pubmed/33404680 http://dx.doi.org/10.1007/s00417-020-05057-0 |
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