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Quantitative analysis of speckle-based X-ray dark-field imaging using numerical wave-optics simulations
The dark-field signal measures the small-angle scattering strength and provides complementary diagnostic information. This is of particular interest for lung imaging due to the pronounced small-angle scatter from the alveolar microstructure. However, most dark-field imaging techniques are relatively...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352882/ https://www.ncbi.nlm.nih.gov/pubmed/34373478 http://dx.doi.org/10.1038/s41598-021-95227-9 |
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author | Meyer, Sebastian Shi, Serena Z. Shapira, Nadav Maidment, Andrew D. A. Noël, Peter B. |
author_facet | Meyer, Sebastian Shi, Serena Z. Shapira, Nadav Maidment, Andrew D. A. Noël, Peter B. |
author_sort | Meyer, Sebastian |
collection | PubMed |
description | The dark-field signal measures the small-angle scattering strength and provides complementary diagnostic information. This is of particular interest for lung imaging due to the pronounced small-angle scatter from the alveolar microstructure. However, most dark-field imaging techniques are relatively complex, dose-inefficient, and require sophisticated optics and highly coherent X-ray sources. Speckle-based imaging promises to overcome these limitations due to its simple and versatile setup, only requiring the addition of a random phase modulator to conventional X-ray equipment. We investigated quantitatively the influence of sample structure, setup geometry, and source energy on the dark-field signal in speckle-based X-ray imaging with wave-optics simulations for ensembles of micro-spheres. We show that the dark-field signal is accurately predicted via a model originally derived for grating interferometry when using the mean frequency of the speckle pattern power spectral density as the characteristic speckle size. The size directly reflects the correlation length of the diffuser surface and did not change with energy or propagation distance within the near-field. The dark-field signal had a distinct dependence on sample structure and setup geometry but was also affected by beam hardening-induced modifications of the visibility spectrum. This study quantitatively demonstrates the behavior of the dark-field signal in speckle-based X-ray imaging. |
format | Online Article Text |
id | pubmed-8352882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83528822021-08-10 Quantitative analysis of speckle-based X-ray dark-field imaging using numerical wave-optics simulations Meyer, Sebastian Shi, Serena Z. Shapira, Nadav Maidment, Andrew D. A. Noël, Peter B. Sci Rep Article The dark-field signal measures the small-angle scattering strength and provides complementary diagnostic information. This is of particular interest for lung imaging due to the pronounced small-angle scatter from the alveolar microstructure. However, most dark-field imaging techniques are relatively complex, dose-inefficient, and require sophisticated optics and highly coherent X-ray sources. Speckle-based imaging promises to overcome these limitations due to its simple and versatile setup, only requiring the addition of a random phase modulator to conventional X-ray equipment. We investigated quantitatively the influence of sample structure, setup geometry, and source energy on the dark-field signal in speckle-based X-ray imaging with wave-optics simulations for ensembles of micro-spheres. We show that the dark-field signal is accurately predicted via a model originally derived for grating interferometry when using the mean frequency of the speckle pattern power spectral density as the characteristic speckle size. The size directly reflects the correlation length of the diffuser surface and did not change with energy or propagation distance within the near-field. The dark-field signal had a distinct dependence on sample structure and setup geometry but was also affected by beam hardening-induced modifications of the visibility spectrum. This study quantitatively demonstrates the behavior of the dark-field signal in speckle-based X-ray imaging. Nature Publishing Group UK 2021-08-09 /pmc/articles/PMC8352882/ /pubmed/34373478 http://dx.doi.org/10.1038/s41598-021-95227-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Meyer, Sebastian Shi, Serena Z. Shapira, Nadav Maidment, Andrew D. A. Noël, Peter B. Quantitative analysis of speckle-based X-ray dark-field imaging using numerical wave-optics simulations |
title | Quantitative analysis of speckle-based X-ray dark-field imaging using numerical wave-optics simulations |
title_full | Quantitative analysis of speckle-based X-ray dark-field imaging using numerical wave-optics simulations |
title_fullStr | Quantitative analysis of speckle-based X-ray dark-field imaging using numerical wave-optics simulations |
title_full_unstemmed | Quantitative analysis of speckle-based X-ray dark-field imaging using numerical wave-optics simulations |
title_short | Quantitative analysis of speckle-based X-ray dark-field imaging using numerical wave-optics simulations |
title_sort | quantitative analysis of speckle-based x-ray dark-field imaging using numerical wave-optics simulations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352882/ https://www.ncbi.nlm.nih.gov/pubmed/34373478 http://dx.doi.org/10.1038/s41598-021-95227-9 |
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