Cargando…
Failure of diffusion-weighted imaging in intraoperative 3 Tesla MRI to identify hyperacute strokes during glioma surgery
Intraoperatively acquired diffusion-weighted imaging (DWI) sequences in cranial tumor surgery are used for early detection of ischemic brain injuries, which could result in impaired neurological outcome and their presence might thus influence the neurosurgeon’s decision on further resection. The phe...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352886/ https://www.ncbi.nlm.nih.gov/pubmed/34373505 http://dx.doi.org/10.1038/s41598-021-95505-6 |
_version_ | 1783736283625947136 |
---|---|
author | Voglis, Stefanos Hiller, Aimee Hofer, Anna-Sophie Tosic, Lazar Bozinov, Oliver Regli, Luca Serra, Carlo |
author_facet | Voglis, Stefanos Hiller, Aimee Hofer, Anna-Sophie Tosic, Lazar Bozinov, Oliver Regli, Luca Serra, Carlo |
author_sort | Voglis, Stefanos |
collection | PubMed |
description | Intraoperatively acquired diffusion-weighted imaging (DWI) sequences in cranial tumor surgery are used for early detection of ischemic brain injuries, which could result in impaired neurological outcome and their presence might thus influence the neurosurgeon’s decision on further resection. The phenomenon of false-negative DWI findings in intraoperative magnetic resonance imaging (ioMRI) has only been reported in single cases and therefore yet needs to be further analyzed. This retrospective single-center study’s objective was the identification and characterization of false-negative DWI findings in ioMRI with new or enlarged ischemic areas on postoperative MRI (poMRI). Out of 225 cranial tumor surgeries with intraoperative DWI sequences, 16 cases with no additional resection after ioMRI and available in-time poMRI (< 14 days) were identified. Of these, a total of 12 cases showed false-negative DWI in ioMRI (75%). The most frequent tumor types were oligodendrogliomas and glioblastomas (4 each). In 5/12 cases (41.7%), an ischemic area was already present in ioMRI, however, volumetrically increased in poMRI (mean infarct growth + 2.1 cm(3); 0.48–3.6), whereas 7 cases (58.3%) harbored totally new infarcts on poMRI (mean infarct volume 0.77 cm(3); 0.05–1.93). With this study we provide the most comprehensive series of false-negative DWI findings in ioMRI that were not followed by additional resection. Our study underlines the limitations of intraoperative DWI sequences for the detection and size-estimation of hyperacute infarction. The awareness of this phenomenon is crucial for any neurosurgeon utilizing ioMRI. |
format | Online Article Text |
id | pubmed-8352886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83528862021-08-10 Failure of diffusion-weighted imaging in intraoperative 3 Tesla MRI to identify hyperacute strokes during glioma surgery Voglis, Stefanos Hiller, Aimee Hofer, Anna-Sophie Tosic, Lazar Bozinov, Oliver Regli, Luca Serra, Carlo Sci Rep Article Intraoperatively acquired diffusion-weighted imaging (DWI) sequences in cranial tumor surgery are used for early detection of ischemic brain injuries, which could result in impaired neurological outcome and their presence might thus influence the neurosurgeon’s decision on further resection. The phenomenon of false-negative DWI findings in intraoperative magnetic resonance imaging (ioMRI) has only been reported in single cases and therefore yet needs to be further analyzed. This retrospective single-center study’s objective was the identification and characterization of false-negative DWI findings in ioMRI with new or enlarged ischemic areas on postoperative MRI (poMRI). Out of 225 cranial tumor surgeries with intraoperative DWI sequences, 16 cases with no additional resection after ioMRI and available in-time poMRI (< 14 days) were identified. Of these, a total of 12 cases showed false-negative DWI in ioMRI (75%). The most frequent tumor types were oligodendrogliomas and glioblastomas (4 each). In 5/12 cases (41.7%), an ischemic area was already present in ioMRI, however, volumetrically increased in poMRI (mean infarct growth + 2.1 cm(3); 0.48–3.6), whereas 7 cases (58.3%) harbored totally new infarcts on poMRI (mean infarct volume 0.77 cm(3); 0.05–1.93). With this study we provide the most comprehensive series of false-negative DWI findings in ioMRI that were not followed by additional resection. Our study underlines the limitations of intraoperative DWI sequences for the detection and size-estimation of hyperacute infarction. The awareness of this phenomenon is crucial for any neurosurgeon utilizing ioMRI. Nature Publishing Group UK 2021-08-09 /pmc/articles/PMC8352886/ /pubmed/34373505 http://dx.doi.org/10.1038/s41598-021-95505-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Voglis, Stefanos Hiller, Aimee Hofer, Anna-Sophie Tosic, Lazar Bozinov, Oliver Regli, Luca Serra, Carlo Failure of diffusion-weighted imaging in intraoperative 3 Tesla MRI to identify hyperacute strokes during glioma surgery |
title | Failure of diffusion-weighted imaging in intraoperative 3 Tesla MRI to identify hyperacute strokes during glioma surgery |
title_full | Failure of diffusion-weighted imaging in intraoperative 3 Tesla MRI to identify hyperacute strokes during glioma surgery |
title_fullStr | Failure of diffusion-weighted imaging in intraoperative 3 Tesla MRI to identify hyperacute strokes during glioma surgery |
title_full_unstemmed | Failure of diffusion-weighted imaging in intraoperative 3 Tesla MRI to identify hyperacute strokes during glioma surgery |
title_short | Failure of diffusion-weighted imaging in intraoperative 3 Tesla MRI to identify hyperacute strokes during glioma surgery |
title_sort | failure of diffusion-weighted imaging in intraoperative 3 tesla mri to identify hyperacute strokes during glioma surgery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352886/ https://www.ncbi.nlm.nih.gov/pubmed/34373505 http://dx.doi.org/10.1038/s41598-021-95505-6 |
work_keys_str_mv | AT voglisstefanos failureofdiffusionweightedimaginginintraoperative3teslamritoidentifyhyperacutestrokesduringgliomasurgery AT hilleraimee failureofdiffusionweightedimaginginintraoperative3teslamritoidentifyhyperacutestrokesduringgliomasurgery AT hoferannasophie failureofdiffusionweightedimaginginintraoperative3teslamritoidentifyhyperacutestrokesduringgliomasurgery AT tosiclazar failureofdiffusionweightedimaginginintraoperative3teslamritoidentifyhyperacutestrokesduringgliomasurgery AT bozinovoliver failureofdiffusionweightedimaginginintraoperative3teslamritoidentifyhyperacutestrokesduringgliomasurgery AT regliluca failureofdiffusionweightedimaginginintraoperative3teslamritoidentifyhyperacutestrokesduringgliomasurgery AT serracarlo failureofdiffusionweightedimaginginintraoperative3teslamritoidentifyhyperacutestrokesduringgliomasurgery |