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External assessment of the EUROMACS right-sided heart failure risk score

The EUROMACS Right-Sided Heart Failure Risk Score was developed to predict right ventricular failure (RVF) after left ventricular assist device (LVAD) placement. The predictive ability of the EUROMACS score has not been tested in other cohorts. We performed a single center analysis of a continuous-f...

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Autores principales: Shah, Hirak, Murray, Thomas, Schultz, Jessica, John, Ranjit, Martin, Cindy M., Thenappan, Thenappan, Cogswell, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352910/
https://www.ncbi.nlm.nih.gov/pubmed/34373475
http://dx.doi.org/10.1038/s41598-021-94792-3
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author Shah, Hirak
Murray, Thomas
Schultz, Jessica
John, Ranjit
Martin, Cindy M.
Thenappan, Thenappan
Cogswell, Rebecca
author_facet Shah, Hirak
Murray, Thomas
Schultz, Jessica
John, Ranjit
Martin, Cindy M.
Thenappan, Thenappan
Cogswell, Rebecca
author_sort Shah, Hirak
collection PubMed
description The EUROMACS Right-Sided Heart Failure Risk Score was developed to predict right ventricular failure (RVF) after left ventricular assist device (LVAD) placement. The predictive ability of the EUROMACS score has not been tested in other cohorts. We performed a single center analysis of a continuous-flow (CF) LVAD cohort (n = 254) where we calculated EUROMACS risk scores and assessed for right ventricular heart failure after LVAD implantation. Thirty-nine percent of patients (100/254) had post-operative RVF, of which 9% (23/254) required prolonged inotropic support and 5% (12/254) required RVAD placement. For patients who developed RVF after LVAD implantation, there was a 45% increase in the hazards of death on LVAD support (HR 1.45, 95% CI 0.98–2.2, p = 0.066). Two variables in the EUROMACS score (Hemoglobin and Right Atrial Pressure to Pulmonary Capillary Wedge Pressure ratio) were not predictive of RVF in our cohort. Overall, the EUROMACS score had poor external discrimination in our cohort with area under the curve of 58% (95% CI 52–66%). Further work is necessary to enhance our ability to predict RVF after LVAD implantation.
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spelling pubmed-83529102021-08-10 External assessment of the EUROMACS right-sided heart failure risk score Shah, Hirak Murray, Thomas Schultz, Jessica John, Ranjit Martin, Cindy M. Thenappan, Thenappan Cogswell, Rebecca Sci Rep Article The EUROMACS Right-Sided Heart Failure Risk Score was developed to predict right ventricular failure (RVF) after left ventricular assist device (LVAD) placement. The predictive ability of the EUROMACS score has not been tested in other cohorts. We performed a single center analysis of a continuous-flow (CF) LVAD cohort (n = 254) where we calculated EUROMACS risk scores and assessed for right ventricular heart failure after LVAD implantation. Thirty-nine percent of patients (100/254) had post-operative RVF, of which 9% (23/254) required prolonged inotropic support and 5% (12/254) required RVAD placement. For patients who developed RVF after LVAD implantation, there was a 45% increase in the hazards of death on LVAD support (HR 1.45, 95% CI 0.98–2.2, p = 0.066). Two variables in the EUROMACS score (Hemoglobin and Right Atrial Pressure to Pulmonary Capillary Wedge Pressure ratio) were not predictive of RVF in our cohort. Overall, the EUROMACS score had poor external discrimination in our cohort with area under the curve of 58% (95% CI 52–66%). Further work is necessary to enhance our ability to predict RVF after LVAD implantation. Nature Publishing Group UK 2021-08-09 /pmc/articles/PMC8352910/ /pubmed/34373475 http://dx.doi.org/10.1038/s41598-021-94792-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Shah, Hirak
Murray, Thomas
Schultz, Jessica
John, Ranjit
Martin, Cindy M.
Thenappan, Thenappan
Cogswell, Rebecca
External assessment of the EUROMACS right-sided heart failure risk score
title External assessment of the EUROMACS right-sided heart failure risk score
title_full External assessment of the EUROMACS right-sided heart failure risk score
title_fullStr External assessment of the EUROMACS right-sided heart failure risk score
title_full_unstemmed External assessment of the EUROMACS right-sided heart failure risk score
title_short External assessment of the EUROMACS right-sided heart failure risk score
title_sort external assessment of the euromacs right-sided heart failure risk score
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352910/
https://www.ncbi.nlm.nih.gov/pubmed/34373475
http://dx.doi.org/10.1038/s41598-021-94792-3
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