No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses

The genetic element s2m has been acquired through horizontal transfer by many distantly related viruses, including the SARS-related coronaviruses. Here we show that s2m is evolutionarily conserved in these viruses. Though several lineages of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑...

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Autores principales: Gilbert, Clément, Tengs, Torstein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352927/
https://www.ncbi.nlm.nih.gov/pubmed/34373516
http://dx.doi.org/10.1038/s41598-021-95496-4
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author Gilbert, Clément
Tengs, Torstein
author_facet Gilbert, Clément
Tengs, Torstein
author_sort Gilbert, Clément
collection PubMed
description The genetic element s2m has been acquired through horizontal transfer by many distantly related viruses, including the SARS-related coronaviruses. Here we show that s2m is evolutionarily conserved in these viruses. Though several lineages of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) devoid of the element can be found, these variants seem to have been short lived, indicating that they were less evolutionary fit than their s2m-containing counterparts. On a species-level, however, there do not appear to be any losses and this pattern strongly suggests that the s2m element is essential to virus replication in SARS-CoV-2 and related viruses. Further experiments are needed to elucidate the function of s2m.
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spelling pubmed-83529272021-08-11 No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses Gilbert, Clément Tengs, Torstein Sci Rep Article The genetic element s2m has been acquired through horizontal transfer by many distantly related viruses, including the SARS-related coronaviruses. Here we show that s2m is evolutionarily conserved in these viruses. Though several lineages of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) devoid of the element can be found, these variants seem to have been short lived, indicating that they were less evolutionary fit than their s2m-containing counterparts. On a species-level, however, there do not appear to be any losses and this pattern strongly suggests that the s2m element is essential to virus replication in SARS-CoV-2 and related viruses. Further experiments are needed to elucidate the function of s2m. Nature Publishing Group UK 2021-08-09 /pmc/articles/PMC8352927/ /pubmed/34373516 http://dx.doi.org/10.1038/s41598-021-95496-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gilbert, Clément
Tengs, Torstein
No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
title No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
title_full No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
title_fullStr No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
title_full_unstemmed No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
title_short No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
title_sort no species-level losses of s2m suggests critical role in replication of sars-related coronaviruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352927/
https://www.ncbi.nlm.nih.gov/pubmed/34373516
http://dx.doi.org/10.1038/s41598-021-95496-4
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