Cargando…

White matter tract-specific alterations in patients with primary restless legs syndrome

Prior diffusion tensor imaging (DTI) studies have investigated white matter (WM) changes in patients with primary restless legs syndrome (RLS), but the results were inconsistent. Here, we proposed using tract-specific statistical analysis (TSSA) to find alterations in specific WM tracts to clarify t...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Hea Ree, Kim, Hye Ryun, Oh, Seunghwan, Seong, Joon-Kyung, Joo, Eun Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352949/
https://www.ncbi.nlm.nih.gov/pubmed/34373482
http://dx.doi.org/10.1038/s41598-021-95238-6
_version_ 1783736299155357696
author Park, Hea Ree
Kim, Hye Ryun
Oh, Seunghwan
Seong, Joon-Kyung
Joo, Eun Yeon
author_facet Park, Hea Ree
Kim, Hye Ryun
Oh, Seunghwan
Seong, Joon-Kyung
Joo, Eun Yeon
author_sort Park, Hea Ree
collection PubMed
description Prior diffusion tensor imaging (DTI) studies have investigated white matter (WM) changes in patients with primary restless legs syndrome (RLS), but the results were inconsistent. Here, we proposed using tract-specific statistical analysis (TSSA) to find alterations in specific WM tracts to clarify the pathophysiological mechanisms of RLS. We enrolled 30 patients with RLS and 31 age- and sex- matched controls who underwent brain magnetic resonance imaging, neuropsychological tests, and polysomnography. Fractional anisotropy (FA) maps obtained from whole-brain diffusion tensor imaging and TSSA were used to localize WM changes in patients with RLS. Subsequently, a comparison of FA values for each tract between patients and controls was performed. The associations between FA values and clinical, polysomnographic, and neuropsychological parameters in RLS patients were assessed. RLS patients demonstrated decreased FA values in the left corticospinal tract (CST) and cingulum, and in the right anterior thalamic radiation (ATR) and inferior fronto-occipital fasciculus (IFO). Patients’ attention/executive function and visual memory scores positively correlated with FA values in the right ATR, and anxiety levels negatively correlated with FA values in the right IFO. Additionally, the number of periodic leg movements and movement arousal index were negatively correlated with FA values in the left CST. The TSSA method identified previously unknown tract-specific alterations in patients with RLS and significant associations with distinct clinical manifestations of RLS.
format Online
Article
Text
id pubmed-8352949
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-83529492021-08-11 White matter tract-specific alterations in patients with primary restless legs syndrome Park, Hea Ree Kim, Hye Ryun Oh, Seunghwan Seong, Joon-Kyung Joo, Eun Yeon Sci Rep Article Prior diffusion tensor imaging (DTI) studies have investigated white matter (WM) changes in patients with primary restless legs syndrome (RLS), but the results were inconsistent. Here, we proposed using tract-specific statistical analysis (TSSA) to find alterations in specific WM tracts to clarify the pathophysiological mechanisms of RLS. We enrolled 30 patients with RLS and 31 age- and sex- matched controls who underwent brain magnetic resonance imaging, neuropsychological tests, and polysomnography. Fractional anisotropy (FA) maps obtained from whole-brain diffusion tensor imaging and TSSA were used to localize WM changes in patients with RLS. Subsequently, a comparison of FA values for each tract between patients and controls was performed. The associations between FA values and clinical, polysomnographic, and neuropsychological parameters in RLS patients were assessed. RLS patients demonstrated decreased FA values in the left corticospinal tract (CST) and cingulum, and in the right anterior thalamic radiation (ATR) and inferior fronto-occipital fasciculus (IFO). Patients’ attention/executive function and visual memory scores positively correlated with FA values in the right ATR, and anxiety levels negatively correlated with FA values in the right IFO. Additionally, the number of periodic leg movements and movement arousal index were negatively correlated with FA values in the left CST. The TSSA method identified previously unknown tract-specific alterations in patients with RLS and significant associations with distinct clinical manifestations of RLS. Nature Publishing Group UK 2021-08-09 /pmc/articles/PMC8352949/ /pubmed/34373482 http://dx.doi.org/10.1038/s41598-021-95238-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Park, Hea Ree
Kim, Hye Ryun
Oh, Seunghwan
Seong, Joon-Kyung
Joo, Eun Yeon
White matter tract-specific alterations in patients with primary restless legs syndrome
title White matter tract-specific alterations in patients with primary restless legs syndrome
title_full White matter tract-specific alterations in patients with primary restless legs syndrome
title_fullStr White matter tract-specific alterations in patients with primary restless legs syndrome
title_full_unstemmed White matter tract-specific alterations in patients with primary restless legs syndrome
title_short White matter tract-specific alterations in patients with primary restless legs syndrome
title_sort white matter tract-specific alterations in patients with primary restless legs syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352949/
https://www.ncbi.nlm.nih.gov/pubmed/34373482
http://dx.doi.org/10.1038/s41598-021-95238-6
work_keys_str_mv AT parkhearee whitemattertractspecificalterationsinpatientswithprimaryrestlesslegssyndrome
AT kimhyeryun whitemattertractspecificalterationsinpatientswithprimaryrestlesslegssyndrome
AT ohseunghwan whitemattertractspecificalterationsinpatientswithprimaryrestlesslegssyndrome
AT seongjoonkyung whitemattertractspecificalterationsinpatientswithprimaryrestlesslegssyndrome
AT jooeunyeon whitemattertractspecificalterationsinpatientswithprimaryrestlesslegssyndrome