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White matter tract-specific alterations in patients with primary restless legs syndrome
Prior diffusion tensor imaging (DTI) studies have investigated white matter (WM) changes in patients with primary restless legs syndrome (RLS), but the results were inconsistent. Here, we proposed using tract-specific statistical analysis (TSSA) to find alterations in specific WM tracts to clarify t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352949/ https://www.ncbi.nlm.nih.gov/pubmed/34373482 http://dx.doi.org/10.1038/s41598-021-95238-6 |
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author | Park, Hea Ree Kim, Hye Ryun Oh, Seunghwan Seong, Joon-Kyung Joo, Eun Yeon |
author_facet | Park, Hea Ree Kim, Hye Ryun Oh, Seunghwan Seong, Joon-Kyung Joo, Eun Yeon |
author_sort | Park, Hea Ree |
collection | PubMed |
description | Prior diffusion tensor imaging (DTI) studies have investigated white matter (WM) changes in patients with primary restless legs syndrome (RLS), but the results were inconsistent. Here, we proposed using tract-specific statistical analysis (TSSA) to find alterations in specific WM tracts to clarify the pathophysiological mechanisms of RLS. We enrolled 30 patients with RLS and 31 age- and sex- matched controls who underwent brain magnetic resonance imaging, neuropsychological tests, and polysomnography. Fractional anisotropy (FA) maps obtained from whole-brain diffusion tensor imaging and TSSA were used to localize WM changes in patients with RLS. Subsequently, a comparison of FA values for each tract between patients and controls was performed. The associations between FA values and clinical, polysomnographic, and neuropsychological parameters in RLS patients were assessed. RLS patients demonstrated decreased FA values in the left corticospinal tract (CST) and cingulum, and in the right anterior thalamic radiation (ATR) and inferior fronto-occipital fasciculus (IFO). Patients’ attention/executive function and visual memory scores positively correlated with FA values in the right ATR, and anxiety levels negatively correlated with FA values in the right IFO. Additionally, the number of periodic leg movements and movement arousal index were negatively correlated with FA values in the left CST. The TSSA method identified previously unknown tract-specific alterations in patients with RLS and significant associations with distinct clinical manifestations of RLS. |
format | Online Article Text |
id | pubmed-8352949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83529492021-08-11 White matter tract-specific alterations in patients with primary restless legs syndrome Park, Hea Ree Kim, Hye Ryun Oh, Seunghwan Seong, Joon-Kyung Joo, Eun Yeon Sci Rep Article Prior diffusion tensor imaging (DTI) studies have investigated white matter (WM) changes in patients with primary restless legs syndrome (RLS), but the results were inconsistent. Here, we proposed using tract-specific statistical analysis (TSSA) to find alterations in specific WM tracts to clarify the pathophysiological mechanisms of RLS. We enrolled 30 patients with RLS and 31 age- and sex- matched controls who underwent brain magnetic resonance imaging, neuropsychological tests, and polysomnography. Fractional anisotropy (FA) maps obtained from whole-brain diffusion tensor imaging and TSSA were used to localize WM changes in patients with RLS. Subsequently, a comparison of FA values for each tract between patients and controls was performed. The associations between FA values and clinical, polysomnographic, and neuropsychological parameters in RLS patients were assessed. RLS patients demonstrated decreased FA values in the left corticospinal tract (CST) and cingulum, and in the right anterior thalamic radiation (ATR) and inferior fronto-occipital fasciculus (IFO). Patients’ attention/executive function and visual memory scores positively correlated with FA values in the right ATR, and anxiety levels negatively correlated with FA values in the right IFO. Additionally, the number of periodic leg movements and movement arousal index were negatively correlated with FA values in the left CST. The TSSA method identified previously unknown tract-specific alterations in patients with RLS and significant associations with distinct clinical manifestations of RLS. Nature Publishing Group UK 2021-08-09 /pmc/articles/PMC8352949/ /pubmed/34373482 http://dx.doi.org/10.1038/s41598-021-95238-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Park, Hea Ree Kim, Hye Ryun Oh, Seunghwan Seong, Joon-Kyung Joo, Eun Yeon White matter tract-specific alterations in patients with primary restless legs syndrome |
title | White matter tract-specific alterations in patients with primary restless legs syndrome |
title_full | White matter tract-specific alterations in patients with primary restless legs syndrome |
title_fullStr | White matter tract-specific alterations in patients with primary restless legs syndrome |
title_full_unstemmed | White matter tract-specific alterations in patients with primary restless legs syndrome |
title_short | White matter tract-specific alterations in patients with primary restless legs syndrome |
title_sort | white matter tract-specific alterations in patients with primary restless legs syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352949/ https://www.ncbi.nlm.nih.gov/pubmed/34373482 http://dx.doi.org/10.1038/s41598-021-95238-6 |
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