Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women

Osteoporosis is one of the chronic and often neglected bone diseases in aging postmenopausal women that affect the quality of life. Studies on ovariectomized mice models indicated the reciprocal role of Th17 cells and Treg cells in the aetiology of osteoporosis. While Th17 cells promote osteoclastog...

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Autores principales: Bhadricha, Hetal, Patel, Vainav, Singh, Amit Kumar, Savardekar, Lalita, Patil, Anushree, Surve, Suchitra, Desai, Meena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352954/
https://www.ncbi.nlm.nih.gov/pubmed/34373550
http://dx.doi.org/10.1038/s41598-021-95640-0
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author Bhadricha, Hetal
Patel, Vainav
Singh, Amit Kumar
Savardekar, Lalita
Patil, Anushree
Surve, Suchitra
Desai, Meena
author_facet Bhadricha, Hetal
Patel, Vainav
Singh, Amit Kumar
Savardekar, Lalita
Patil, Anushree
Surve, Suchitra
Desai, Meena
author_sort Bhadricha, Hetal
collection PubMed
description Osteoporosis is one of the chronic and often neglected bone diseases in aging postmenopausal women that affect the quality of life. Studies on ovariectomized mice models indicated the reciprocal role of Th17 cells and Treg cells in the aetiology of osteoporosis. While Th17 cells promote osteoclastogenesis, Treg cells exhibit anti-osteoclastogenic activity. This exploratory study aimed to determine the difference in the frequency of these T-cell subtypes in pre-and postmenopausal women and to examine their association with BMD. In our study, the frequency of Treg cells, analyzed by flow cytometry, did not differ between pre-and postmenopausal women. However, plasma levels of IL-10 along with IL-10(+)CD4(+)T cells were higher in post- compared to premenopausal women. The frequency of Th17 cells was higher in postmenopausal women irrespective of their BMD, however, only postmenopausal women with low BMD had elevated IL-17 levels and their T-scores were associated with Th17 frequency. Collectively, the results suggest that estrogen insufficiency in postmenopausal women may lead to increased Th17 cell frequency and elevated IL-17 levels which are associated with low BMD. This study highlights, Th17 cells and IL-17 as key players in the pathogenesis of osteoporosis and they can be the potential targets for immunotherapy in the treatment of osteoporosis.
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spelling pubmed-83529542021-08-11 Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women Bhadricha, Hetal Patel, Vainav Singh, Amit Kumar Savardekar, Lalita Patil, Anushree Surve, Suchitra Desai, Meena Sci Rep Article Osteoporosis is one of the chronic and often neglected bone diseases in aging postmenopausal women that affect the quality of life. Studies on ovariectomized mice models indicated the reciprocal role of Th17 cells and Treg cells in the aetiology of osteoporosis. While Th17 cells promote osteoclastogenesis, Treg cells exhibit anti-osteoclastogenic activity. This exploratory study aimed to determine the difference in the frequency of these T-cell subtypes in pre-and postmenopausal women and to examine their association with BMD. In our study, the frequency of Treg cells, analyzed by flow cytometry, did not differ between pre-and postmenopausal women. However, plasma levels of IL-10 along with IL-10(+)CD4(+)T cells were higher in post- compared to premenopausal women. The frequency of Th17 cells was higher in postmenopausal women irrespective of their BMD, however, only postmenopausal women with low BMD had elevated IL-17 levels and their T-scores were associated with Th17 frequency. Collectively, the results suggest that estrogen insufficiency in postmenopausal women may lead to increased Th17 cell frequency and elevated IL-17 levels which are associated with low BMD. This study highlights, Th17 cells and IL-17 as key players in the pathogenesis of osteoporosis and they can be the potential targets for immunotherapy in the treatment of osteoporosis. Nature Publishing Group UK 2021-08-09 /pmc/articles/PMC8352954/ /pubmed/34373550 http://dx.doi.org/10.1038/s41598-021-95640-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Bhadricha, Hetal
Patel, Vainav
Singh, Amit Kumar
Savardekar, Lalita
Patil, Anushree
Surve, Suchitra
Desai, Meena
Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women
title Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women
title_full Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women
title_fullStr Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women
title_full_unstemmed Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women
title_short Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women
title_sort increased frequency of th17 cells and il-17 levels are associated with low bone mineral density in postmenopausal women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352954/
https://www.ncbi.nlm.nih.gov/pubmed/34373550
http://dx.doi.org/10.1038/s41598-021-95640-0
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