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A new insight into aggregation of oncolytic adenovirus Ad5-delta-24-RGD during CsCl gradient ultracentrifugation

Two-cycle cesium chloride (2 × CsCl) gradient ultracentrifugation is a conventional approach for purifying recombinant adenoviruses (rAds) for research purposes (gene therapy, vaccines, and oncolytic vectors). However, rAds containing the RGD-4C peptide in the HI loop of the fiber knob domain tend t...

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Detalles Bibliográficos
Autores principales:	Stepanenko, Aleksei A., Sosnovtseva, Anastasiia O., Valikhov, Marat P., Chekhonin, Vladimir P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352973/ https://www.ncbi.nlm.nih.gov/pubmed/34373477 http://dx.doi.org/10.1038/s41598-021-94573-y

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