Cargando…
Estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka
The preoptic area (POA) is one of the most evolutionarily conserved regions of the vertebrate brain and contains subsets of neuropeptide-expressing neurons. Here we found in the teleost medaka that two neuropeptides belonging to the secretin family, pituitary adenylate cyclase-activating polypeptide...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352984/ https://www.ncbi.nlm.nih.gov/pubmed/34373576 http://dx.doi.org/10.1038/s42003-021-02476-5 |
_version_ | 1783736309843492864 |
---|---|
author | Yamashita, Junpei Nishiike, Yuji Fleming, Thomas Kayo, Daichi Okubo, Kataaki |
author_facet | Yamashita, Junpei Nishiike, Yuji Fleming, Thomas Kayo, Daichi Okubo, Kataaki |
author_sort | Yamashita, Junpei |
collection | PubMed |
description | The preoptic area (POA) is one of the most evolutionarily conserved regions of the vertebrate brain and contains subsets of neuropeptide-expressing neurons. Here we found in the teleost medaka that two neuropeptides belonging to the secretin family, pituitary adenylate cyclase-activating polypeptide (Pacap) and vasoactive intestinal peptide (Vip), exhibit opposite patterns of sexually dimorphic expression in the same population of POA neurons that project to the anterior pituitary: Pacap is male-biased, whereas Vip is female-biased. Estrogen secreted by the ovary in adulthood was found to attenuate Pacap expression and, conversely, stimulate Vip expression in the female POA, thereby establishing and maintaining their opposite sexual dimorphism. Pituitary organ culture experiments demonstrated that both Pacap and Vip can markedly alter the expression of various anterior pituitary hormones. Collectively, these findings show that males and females use alternative preoptic neuropeptides to regulate anterior pituitary hormones as a result of their different estrogen milieu. |
format | Online Article Text |
id | pubmed-8352984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83529842021-08-13 Estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka Yamashita, Junpei Nishiike, Yuji Fleming, Thomas Kayo, Daichi Okubo, Kataaki Commun Biol Article The preoptic area (POA) is one of the most evolutionarily conserved regions of the vertebrate brain and contains subsets of neuropeptide-expressing neurons. Here we found in the teleost medaka that two neuropeptides belonging to the secretin family, pituitary adenylate cyclase-activating polypeptide (Pacap) and vasoactive intestinal peptide (Vip), exhibit opposite patterns of sexually dimorphic expression in the same population of POA neurons that project to the anterior pituitary: Pacap is male-biased, whereas Vip is female-biased. Estrogen secreted by the ovary in adulthood was found to attenuate Pacap expression and, conversely, stimulate Vip expression in the female POA, thereby establishing and maintaining their opposite sexual dimorphism. Pituitary organ culture experiments demonstrated that both Pacap and Vip can markedly alter the expression of various anterior pituitary hormones. Collectively, these findings show that males and females use alternative preoptic neuropeptides to regulate anterior pituitary hormones as a result of their different estrogen milieu. Nature Publishing Group UK 2021-08-09 /pmc/articles/PMC8352984/ /pubmed/34373576 http://dx.doi.org/10.1038/s42003-021-02476-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Yamashita, Junpei Nishiike, Yuji Fleming, Thomas Kayo, Daichi Okubo, Kataaki Estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka |
title | Estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka |
title_full | Estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka |
title_fullStr | Estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka |
title_full_unstemmed | Estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka |
title_short | Estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka |
title_sort | estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352984/ https://www.ncbi.nlm.nih.gov/pubmed/34373576 http://dx.doi.org/10.1038/s42003-021-02476-5 |
work_keys_str_mv | AT yamashitajunpei estrogenmediatessexdifferencesinpreopticneuropeptideandpituitaryhormoneproductioninmedaka AT nishiikeyuji estrogenmediatessexdifferencesinpreopticneuropeptideandpituitaryhormoneproductioninmedaka AT flemingthomas estrogenmediatessexdifferencesinpreopticneuropeptideandpituitaryhormoneproductioninmedaka AT kayodaichi estrogenmediatessexdifferencesinpreopticneuropeptideandpituitaryhormoneproductioninmedaka AT okubokataaki estrogenmediatessexdifferencesinpreopticneuropeptideandpituitaryhormoneproductioninmedaka |