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Minimally invasive quantification of cerebral P2X7R occupancy using dynamic [(18)F]JNJ-64413739 PET and MRA-driven image derived input function

[(18)F]JNJ-64413739 has been evaluated as PET-ligand for in vivo quantification of purinergic receptor subtype 7 receptor (P2X7R) using Logan graphical analysis with a metabolite-corrected arterial plasma input function. In the context of a P2X7R PET dose occupancy study, we evaluated a minimally in...

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Detalles Bibliográficos
Autores principales:	Mertens, Nathalie, Schmidt, Mark E., Hijzen, Anja, Van Weehaeghe, Donatienne, Ravenstijn, Paulien, Depre, Marleen, de Hoon, Jan, Van Laere, Koen, Koole, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352986/ https://www.ncbi.nlm.nih.gov/pubmed/34373571 http://dx.doi.org/10.1038/s41598-021-95715-y

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