Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease

People of recent sub-Saharan African ancestry develop kidney failure much more frequently than other groups. A large fraction of this disparity is due to two coding sequence variants in the APOL1 gene. Inheriting two copies of these APOL1 risk variants, known as G1 and G2, causes high rates of focal...

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Detalles Bibliográficos
Autores principales: McCarthy, Gizelle M., Blasio, Angelo, Donovan, Olivia G., Schaller, Lena B., Bock-Hughes, Althea, Magraner, Jose M., Suh, Jung Hee, Tattersfield, Calum F., Stillman, Isaac E., Shah, Shrijal S., Zsengeller, Zsuzsanna K., Subramanian, Balajikarthick, Friedman, David J., Pollak, Martin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353097/
https://www.ncbi.nlm.nih.gov/pubmed/34350953
http://dx.doi.org/10.1242/dmm.048952

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