Combined Blockade of GARP:TGF-β1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP(+) Blood Vessels in Mouse MC38 Tumors

When combined with anti-PD-1, monoclonal antibodies (mAbs) against GARP:TGF-β1 complexes induced more frequent immune-mediated rejections of CT26 and MC38 murine tumors than anti-PD-1 alone. In both types of tumors, the activity of anti-GARP:TGF-β1 mAbs resulted from blocking active TGF-β1 productio...

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Detalles Bibliográficos
Autores principales: Bertrand, Charlotte, Van Meerbeeck, Pierre, de Streel, Grégoire, Vaherto-Bleeckx, Noora, Benhaddi, Fatima, Rouaud, Loïc, Noël, Agnès, Coulie, Pierre G., van Baren, Nicolas, Lucas, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353334/
https://www.ncbi.nlm.nih.gov/pubmed/34386010
http://dx.doi.org/10.3389/fimmu.2021.704050

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