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Assessing reversible and irreversible binding effects of kinase covalent inhibitors through ADP-Glo assays
Typical enzymatic inhibition assays often demonstrate improved potency for kinase covalent inhibitors compared to reversible inhibitors. This can primarily be attributed to the irreversible mode of action and could affect the evaluations of the ATP-competitive nature of covalent inhibitors, hinderin...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353353/ https://www.ncbi.nlm.nih.gov/pubmed/34401783 http://dx.doi.org/10.1016/j.xpro.2021.100717 |