Multiple Roles of Brd4 in the Infectious Cycle of Human Papillomaviruses

Human Papillomaviruses (HPV) reproduce in stratified epithelia by establishing a reservoir of low- level infection in the dividing basal cells and restricting the production of viral particles to terminally differentiated cells. These small DNA viruses hijack pivotal cellular processes and pathways...

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Autores principales: McBride, Alison A., Warburton, Alix, Khurana, Simran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353396/
https://www.ncbi.nlm.nih.gov/pubmed/34386523
http://dx.doi.org/10.3389/fmolb.2021.725794
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author McBride, Alison A.
Warburton, Alix
Khurana, Simran
author_facet McBride, Alison A.
Warburton, Alix
Khurana, Simran
author_sort McBride, Alison A.
collection PubMed
description Human Papillomaviruses (HPV) reproduce in stratified epithelia by establishing a reservoir of low- level infection in the dividing basal cells and restricting the production of viral particles to terminally differentiated cells. These small DNA viruses hijack pivotal cellular processes and pathways to support the persistent infectious cycle. One cellular factor that is key to multiple stages of viral replication and transcription is the BET (bromodomain and extra-terminal domain) protein, Brd4 (Bromodomain containing protein 4). Here we provide an overview of the multiple interactions of Brd4 that occur throughout the HPV infectious cycle.
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spelling pubmed-83533962021-08-11 Multiple Roles of Brd4 in the Infectious Cycle of Human Papillomaviruses McBride, Alison A. Warburton, Alix Khurana, Simran Front Mol Biosci Molecular Biosciences Human Papillomaviruses (HPV) reproduce in stratified epithelia by establishing a reservoir of low- level infection in the dividing basal cells and restricting the production of viral particles to terminally differentiated cells. These small DNA viruses hijack pivotal cellular processes and pathways to support the persistent infectious cycle. One cellular factor that is key to multiple stages of viral replication and transcription is the BET (bromodomain and extra-terminal domain) protein, Brd4 (Bromodomain containing protein 4). Here we provide an overview of the multiple interactions of Brd4 that occur throughout the HPV infectious cycle. Frontiers Media S.A. 2021-07-27 /pmc/articles/PMC8353396/ /pubmed/34386523 http://dx.doi.org/10.3389/fmolb.2021.725794 Text en Copyright © 2021 McBride, Warburton and Khurana. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
McBride, Alison A.
Warburton, Alix
Khurana, Simran
Multiple Roles of Brd4 in the Infectious Cycle of Human Papillomaviruses
title Multiple Roles of Brd4 in the Infectious Cycle of Human Papillomaviruses
title_full Multiple Roles of Brd4 in the Infectious Cycle of Human Papillomaviruses
title_fullStr Multiple Roles of Brd4 in the Infectious Cycle of Human Papillomaviruses
title_full_unstemmed Multiple Roles of Brd4 in the Infectious Cycle of Human Papillomaviruses
title_short Multiple Roles of Brd4 in the Infectious Cycle of Human Papillomaviruses
title_sort multiple roles of brd4 in the infectious cycle of human papillomaviruses
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353396/
https://www.ncbi.nlm.nih.gov/pubmed/34386523
http://dx.doi.org/10.3389/fmolb.2021.725794
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