Cargando…

Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, With Insights Into Its Signaling Mechanisms Using In Silico Analysis

Background: Atherosclerosis (AS), a major risk factor for stroke and brain tissue destruction, is an inflammatory disease of the blood vessels, and the underlying pathology is inflammation mediated by various chemokines and cytokines. Quercetin, a natural flavonol, is reported to have both anti-infl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huwait, Etimad A., Saddeek, Salma Y., Al-Massabi, Rehab F., Almowallad, Sanaa J., Pushparaj, Peter Natesan, Kalamegam, Gauthaman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353397/ https://www.ncbi.nlm.nih.gov/pubmed/34385920 http://dx.doi.org/10.3389/fphar.2021.698138

Ejemplares similares

Punicalagin Targets Atherosclerosis: Gene Expression Profiling of THP-1 Macrophages Treated with Punicalagin and Molecular Docking
por: Huwait, Etimad, et al.
Publicado: (2022)

Punicalagin Regulates Key Processes Associated with Atherosclerosis in THP-1 Cellular Model
por: Almowallad, Sanaa, et al.
Publicado: (2020)

Microarray Expression Profile of Myricetin-Treated THP-1 Macrophages Exhibits Alterations in Atherosclerosis-Related Regulator Molecules and LXR/RXR Pathway
por: Huwait, Etimad, et al.
Publicado: (2022)

Atheroprotective Effect of Fucoidan in THP-1 Macrophages by Potential Upregulation of ABCA1
por: Mirza, Zeenat, et al.
Publicado: (2023)

Thymoquinone (TQ) Inhibits Inflammation and Migration of THP-1 Macrophages: Mechanistic Insights into the Prevention of Atherosclerosis Using In-Vitro and In-Silico Analysis
por: Huwait, Etimad, et al.
Publicado: (2022)

Investigation of the Molecular Mechanisms Underlying the Antiatherogenic Actions of Kaempferol in Human THP-1 Macrophages
por: Huwait, Etimad, et al.
Publicado: (2022)

Integration of palliative care in the management of oral squamous cell carcinoma
por: Sridhar, Republica, et al.
Publicado: (2023)

Editorial: Methods and application in integrative and regenerative pharmacology: 2021
por: Pushparaj, Peter Natesan, et al.
Publicado: (2022)

Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia
por: Pushparaj, Peter Natesan, et al.
Publicado: (2022)

In vitro Evaluation of the Anti-inflammatory Effects of Thymoquinone in Osteoarthritis and in silico Analysis of Inter-Related Pathways in Age-Related Degenerative Diseases
por: Kalamegam, Gauthaman, et al.
Publicado: (2020)

Anti-Inflammatory Potential of Fucoidan for Atherosclerosis: In Silico and In Vitro Studies in THP-1 Cells
por: Huwait, Etimad, et al.
Publicado: (2022)

Unraveling the Catha edulis Extract Effects on the Cellular and Molecular Signaling in SKOV3 Cells
por: Abou-Elhamd, Alaa Sayed, et al.
Publicado: (2021)

Role of the antineoplastic drug bleomycin based on toxicogenomic-DNA damage inducing (TGx-DDI) genomic biomarkers data: A meta-analysis
por: Pushparaj, Peter Natesan, et al.
Publicado: (2023)

Exploration of potential molecular mechanisms and genotoxicity of anti-cancer drugs using next generation knowledge discovery methods
por: Pushparaj, Peter Natesan, et al.
Publicado: (2023)

Role of Oxidative Stress and the Identification of Biomarkers Associated With Thyroid Dysfunction in Schizophrenics
por: Rasool, Mahmood, et al.
Publicado: (2021)

In-Silico Characterization and in-Vivo Validation of Albiziasaponin-A, Iso-Orientin, and Salvadorin Using a Rat Model of Alzheimer's Disease
por: Rasool, Mahmood, et al.
Publicado: (2018)

Primary ovarian cancer cell inhibition by human Wharton's Jelly stem cells (hWJSCs): Mapping probable mechanisms and targets using systems oncology
por: Kalamegam, Gauthaman, et al.
Publicado: (2015)

Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest
por: Khan, Fazal, et al.
Publicado: (2016)

Molecular docking of resveratrol with known protein structures as well as high-throughput meta-data analyses uncork the “French Paradox” and its potential “Druggable” targets in humans
por: Pushparaj, Peter Natesan, et al.
Publicado: (2014)

Disease associated cellular machinery in anaphylaxis – And the de novo paradigm shift
por: Pushparaj, Peter Natesan, et al.
Publicado: (2015)

WTAP mediates the anti-inflammatory effect of Astragalus mongholicus polysaccharide on THP-1 macrophages
por: Long, Haijiao, et al.
Publicado: (2022)

Evaluation of in vitro chondrocytic differentiation: A stem cell research initiative at the King Abdulaziz University, Kingdom of Saudi Arabia
por: Al-Yamani, Aisha, et al.
Publicado: (2018)

Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats
por: Khan, Fazal, et al.
Publicado: (2017)

Role of ZNF143 and Its Association with Gene Expression Patterns, Noncoding Mutations, and the Immune System in Human Breast Cancer
por: Saddeek, Salma, et al.
Publicado: (2022)

Identification of Novel Gene Signatures using Next-Generation Sequencing Data from COVID-19 Infection Models: Focus on Neuro-COVID and Potential Therapeutics
por: Pushparaj, Peter Natesan, et al.
Publicado: (2021)

Quercetin Alleviates Pulmonary Fibrosis in Mice Exposed to Silica by Inhibiting Macrophage Senescence
por: Geng, Fei, et al.
Publicado: (2022)

Cytokines secreted by human Wharton's jelly stem cells inhibit the proliferation of ovarian cancer (OVCAR3) cells in vitro
por: Kalamegam, Gauthaman, et al.
Publicado: (2019)

Evaluation of anti-inflammatory effect of Varanadi Kashayam (decoction) in THP-1-derived macrophages
por: Chinchu, J. U., et al.
Publicado: (2018)

Potential and Therapeutic Roles of Diosmin in Human Diseases
por: Huwait, Etimad, et al.
Publicado: (2022)

Deciphering the Association of Cytokines, Chemokines, and Growth Factors in Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Using an ex vivo Osteochondral Culture System
por: Jafri, Mohammad Alam, et al.
Publicado: (2020)

Antiatherogenic effects of vitamin E: the search for the Holy Grail
por: Kirmizis, Dimitrios, et al.
Publicado: (2009)

Paraoxonase: Its antiatherogenic role in chronic renal failure
por: Prakash, M., et al.
Publicado: (2010)

On the antiatherogenic effects of vitamin E: the search for the Holy Grail
por: Galli, Francesco
Publicado: (2010)

Advances in the Study of the Antiatherogenic Function and Novel Therapies for HDL
por: Cao, Peiqiu, et al.
Publicado: (2015)

Antiatherogenic Properties of Acetone Extract of Alpinia zerumbet Seeds
por: Chompoo, Jamnian, et al.
Publicado: (2012)

The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice
por: Li, Xi, et al.
Publicado: (2018)

Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages
por: Wang, Limei, et al.
Publicado: (2017)

The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability
por: Wang, Limei, et al.
Publicado: (2017)

L-cystathionine protects against oxidative stress and DNA damage induced by oxidized low-density lipoprotein in THP-1-derived macrophages
por: Peng, Hanlin, et al.
Publicado: (2023)

Human Wharton's Jelly Stem Cell (hWJSC) Extracts Inhibit Ovarian Cancer Cell Lines OVCAR3 and SKOV3 in vitro by Inducing Cell Cycle Arrest and Apoptosis
por: Kalamegam, Gauthaman, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0vhkuc88dusjpfqegrd4qvi0ov