Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case report

BACKGROUND: The true burden and geographical distribution of human Borna disease virus 1 (BoDV-1) encephalitis is unknown. All detected cases so far have been recorded in Bavaria, southern Germany. CASE PRESENTATION: A retrospective laboratory and epidemiological investigation of a 2017 case of fata...

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Autores principales: Tappe, Dennis, Pörtner, Kirsten, Frank, Christina, Wilking, Hendrik, Ebinger, Arnt, Herden, Christiane, Schulze, Christoph, Muntau, Birgit, Eggert, Petra, Allartz, Petra, Schuldt, Gerlind, Schmidt-Chanasit, Jonas, Beer, Martin, Rubbenstroth, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353434/
https://www.ncbi.nlm.nih.gov/pubmed/34376142
http://dx.doi.org/10.1186/s12879-021-06439-3
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author Tappe, Dennis
Pörtner, Kirsten
Frank, Christina
Wilking, Hendrik
Ebinger, Arnt
Herden, Christiane
Schulze, Christoph
Muntau, Birgit
Eggert, Petra
Allartz, Petra
Schuldt, Gerlind
Schmidt-Chanasit, Jonas
Beer, Martin
Rubbenstroth, Dennis
author_facet Tappe, Dennis
Pörtner, Kirsten
Frank, Christina
Wilking, Hendrik
Ebinger, Arnt
Herden, Christiane
Schulze, Christoph
Muntau, Birgit
Eggert, Petra
Allartz, Petra
Schuldt, Gerlind
Schmidt-Chanasit, Jonas
Beer, Martin
Rubbenstroth, Dennis
author_sort Tappe, Dennis
collection PubMed
description BACKGROUND: The true burden and geographical distribution of human Borna disease virus 1 (BoDV-1) encephalitis is unknown. All detected cases so far have been recorded in Bavaria, southern Germany. CASE PRESENTATION: A retrospective laboratory and epidemiological investigation of a 2017 case of fatal encephalitis in a farmer in Brandenburg, northeast Germany, demonstrated BoDV-1 as causative agent by polymerase chain reaction, immunohistochemistry and in situ hybridization. Next-generation sequencing showed that the virus belonged to a cluster not known to be endemic in Brandenburg. The investigation was triggered by a recent outbreak of animal Borna disease in the region. Multiple possible exposures were identified. The next-of-kin were seronegative. CONCLUSIONS: The investigation highlights clinical awareness for human BoDV-1 encephalitis which should be extended to all areas endemic for animal Borna disease. All previously diagnosed human cases had occurred > 350 km further south. Further testing of shrews and livestock with Borna disease may show whether this BoDV-1 cluster is additionally endemic in the northwest of Brandenburg.
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spelling pubmed-83534342021-08-10 Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case report Tappe, Dennis Pörtner, Kirsten Frank, Christina Wilking, Hendrik Ebinger, Arnt Herden, Christiane Schulze, Christoph Muntau, Birgit Eggert, Petra Allartz, Petra Schuldt, Gerlind Schmidt-Chanasit, Jonas Beer, Martin Rubbenstroth, Dennis BMC Infect Dis Case Report BACKGROUND: The true burden and geographical distribution of human Borna disease virus 1 (BoDV-1) encephalitis is unknown. All detected cases so far have been recorded in Bavaria, southern Germany. CASE PRESENTATION: A retrospective laboratory and epidemiological investigation of a 2017 case of fatal encephalitis in a farmer in Brandenburg, northeast Germany, demonstrated BoDV-1 as causative agent by polymerase chain reaction, immunohistochemistry and in situ hybridization. Next-generation sequencing showed that the virus belonged to a cluster not known to be endemic in Brandenburg. The investigation was triggered by a recent outbreak of animal Borna disease in the region. Multiple possible exposures were identified. The next-of-kin were seronegative. CONCLUSIONS: The investigation highlights clinical awareness for human BoDV-1 encephalitis which should be extended to all areas endemic for animal Borna disease. All previously diagnosed human cases had occurred > 350 km further south. Further testing of shrews and livestock with Borna disease may show whether this BoDV-1 cluster is additionally endemic in the northwest of Brandenburg. BioMed Central 2021-08-10 /pmc/articles/PMC8353434/ /pubmed/34376142 http://dx.doi.org/10.1186/s12879-021-06439-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Tappe, Dennis
Pörtner, Kirsten
Frank, Christina
Wilking, Hendrik
Ebinger, Arnt
Herden, Christiane
Schulze, Christoph
Muntau, Birgit
Eggert, Petra
Allartz, Petra
Schuldt, Gerlind
Schmidt-Chanasit, Jonas
Beer, Martin
Rubbenstroth, Dennis
Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case report
title Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case report
title_full Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case report
title_fullStr Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case report
title_full_unstemmed Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case report
title_short Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case report
title_sort investigation of fatal human borna disease virus 1 encephalitis outside the previously known area for human cases, brandenburg, germany – a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353434/
https://www.ncbi.nlm.nih.gov/pubmed/34376142
http://dx.doi.org/10.1186/s12879-021-06439-3
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