Cargando…

Follistatin Attenuates Myocardial Fibrosis in Diabetic Cardiomyopathy via the TGF-β–Smad3 Pathway

Follistatin (FST) is an endogenous protein that irreversibly inhibits TGF-β superfamily members and plays an anti-fibrotic role in other diseases. However, the role of FST in diabetic cardiomyopathy remains unclear. In this study, we investigated the effects of FST on diabetic cardiomyopathy. The ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yinhui, Yu, Kun, Zhao, Chengcheng, Zhou, Ling, Cheng, Jia, Wang, Dao Wen, Zhao, Chunxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353454/ https://www.ncbi.nlm.nih.gov/pubmed/34385917 http://dx.doi.org/10.3389/fphar.2021.683335

Ejemplares similares

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

Blueberry Juice Attenuates Pulmonary Fibrosis via Blocking the TGF-β1/Smad Signaling Pathway
por: Li, Yali, et al.
Publicado: (2022)

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis
por: Walton, Kelly L., et al.
Publicado: (2017)

Dapagliflozin Attenuates Myocardial Fibrosis by Inhibiting the TGF-β1/Smad Signaling Pathway in a Normoglycemic Rabbit Model of Chronic Heart Failure
por: Chen, Xuefeng, et al.
Publicado: (2022)

Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway
por: Pan, Jianheng, et al.
Publicado: (2021)

Mechanism of action of non-coding RNAs and traditional Chinese medicine in myocardial fibrosis: Focus on the TGF-β/Smad signaling pathway
por: Li, Chunjun, et al.
Publicado: (2023)

Wenfei Buqi Tongluo Formula Against Bleomycin-Induced Pulmonary Fibrosis by Inhibiting TGF-β/Smad3 Pathway
por: Ding, Lu, et al.
Publicado: (2022)

Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling
por: Huang, Qian, et al.
Publicado: (2022)

Effects of Nervilia fordii Extract on Pulmonary Fibrosis Through TGF-β/Smad Signaling Pathway
por: Yao, Yufeng, et al.
Publicado: (2021)

Irbesartan ameliorates myocardial fibrosis in diabetic cardiomyopathy rats by inhibiting the TGFβ1/Smad2/3 pathway
por: Zong, Min, et al.
Publicado: (2020)

Metformin Ameliorates Chronic Colitis-Related Intestinal Fibrosis via Inhibiting TGF-β1/Smad3 Signaling
por: Wang, Ying, et al.
Publicado: (2022)

Rhubarb Protect Against Tubulointerstitial Fibrosis by Inhibiting TGF-β/Smad Pathway and Improving Abnormal Metabolome in Chronic Kidney Disease
por: Zhang, Zhi-Hao, et al.
Publicado: (2018)

ACPA Alleviates Bleomycin-Induced Pulmonary Fibrosis by Inhibiting TGF-β-Smad2/3 Signaling-Mediated Lung Fibroblast Activation
por: Chen, Dongxin, et al.
Publicado: (2022)

Yougui Pills Attenuate Cartilage Degeneration via Activation of TGF-β/Smad Signaling in Chondrocyte of Osteoarthritic Mouse Model
por: Zhang, Lei, et al.
Publicado: (2017)

2-Arachidonoylglycerol Attenuates Myocardial Fibrosis in Diabetic Mice Via the TGF-β1/Smad Pathway
por: Chen, Zhengjie, et al.
Publicado: (2022)

Suppression of TGF-β(1)/Smad Signaling Pathway by Sesamin Contributes to the Attenuation of Myocardial Fibrosis in Spontaneously Hypertensive Rats
por: Zhao, Mengqiu, et al.
Publicado: (2015)

Protective Effects of Sacubitril/Valsartan on Cardiac Fibrosis and Function in Rats With Experimental Myocardial Infarction Involves Inhibition of Collagen Synthesis by Myocardial Fibroblasts Through Downregulating TGF-β1/Smads Pathway
por: Wu, Meifang, et al.
Publicado: (2021)

GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGFβ1/Smad-Mediated Epithelial-to-Mesenchymal Transition
por: Zhou, Xiao-Ming, et al.
Publicado: (2017)

Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization
por: Yang, Hong-Xia, et al.
Publicado: (2021)

Polyporus Polysaccharide Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing Myofibroblast Differentiation via TGF-β/Smad2/3 Pathway
por: Jiang, Jintao, et al.
Publicado: (2020)

Catalpol Protects Against Pulmonary Fibrosis Through Inhibiting TGF-β1/Smad3 and Wnt/β-Catenin Signaling Pathways
por: Yang, Fan, et al.
Publicado: (2021)

Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo
por: Yang, Fan, et al.
Publicado: (2017)

Tyrosine kinase receptor B attenuates liver fibrosis by inhibiting TGF-β/SMAD signaling
por: Song, Yu, et al.
Publicado: (2023)

Over-Expression of Inhibitor of Differentiation 2 Attenuates Post-Infarct Cardiac Fibrosis Through Inhibition of TGF-β1/Smad3/HIF-1α/IL-11 Signaling Pathway
por: Yin, Lin, et al.
Publicado: (2019)

Matrine suppresses cardiac fibrosis by inhibiting the TGF-β/Smad pathway in experimental diabetic cardiomyopathy
por: Zhang, Yong, et al.
Publicado: (2018)

Strontium Regulates the Proliferation and Differentiation of Isolated Primary Bovine Chondrocytes via the TGFβ/SMAD Pathway
por: Liu, Siqi, et al.
Publicado: (2022)

Combination Therapy of Alpha-Lipoic Acid, Gliclazide and Ramipril Protects Against Development of Diabetic Cardiomyopathy via Inhibition of TGF-β/Smad Pathway
por: Dugbartey, George J., et al.
Publicado: (2022)

Acupuncture attenuates renal interstitial fibrosis via the TGF-β/Smad pathway
por: Zuo, Zheng, et al.
Publicado: (2019)

Aspirin attenuates liver fibrosis by suppressing TGF-β1/Smad signaling
por: Sun, Yimin, et al.
Publicado: (2022)

Induced Pluripotent Stem Cells Inhibit Bleomycin-Induced Pulmonary Fibrosis in Mice through Suppressing TGF-β1/Smad-Mediated Epithelial to Mesenchymal Transition
por: Zhou, Yan, et al.
Publicado: (2016)

Tangshen Formula Improves Diabetes-Associated Myocardial Fibrosis by Inhibiting TGF-β/Smads and Wnt/β-Catenin Pathways
por: Hu, Lin, et al.
Publicado: (2021)

Magnesium Isoglycyrrhizinate Ameliorates Fibrosis and Disrupts TGF-β-Mediated SMAD Pathway in Activated Hepatic Stellate Cell Line LX2
por: Tee, Jie Kai, et al.
Publicado: (2018)

Shenkang Injection for Treating Renal Fibrosis-Metabonomics and Regulation of E3 Ubiquitin Ligase Smurfs on TGF-β/Smads Signal Transduction
por: Zou, Junju, et al.
Publicado: (2022)

CD82 attenuates TGF-β1-mediated epithelial-mesenchymal transition by blocking smad-dependent signaling in ARPE-19 cells
por: Lee, Hyesook, et al.
Publicado: (2022)

MicroRNA-130a attenuates cardiac fibrosis after myocardial infarction through TGF-β/Smad signaling by directly targeting TGF-β receptor 1
por: Feng, Yu, et al.
Publicado: (2022)

Fenofibrate Inhibits Subretinal Fibrosis Through Suppressing TGF‐β—Smad2/3 signaling and Wnt signaling in Neovascular Age‐Related Macular Degeneration
por: Chen, Qian, et al.
Publicado: (2020)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways
por: Yang, Linli, et al.
Publicado: (2020)

Obg-Like ATPase 1 Enhances Chemoresistance of Breast Cancer via Activation of TGF-β/Smad Axis Cascades
por: Liu, Jianzhou, et al.
Publicado: (2020)

Saikosaponin D Inhibits Peritoneal Fibrosis in Rats With Renal Failure by Regulation of TGFβ1/ BMP7 / Gremlin1/ Smad Pathway
por: Ruiqi, Liu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_aat1gfbtrim79r0gsadnegul55