Inhibition of β-Catenin/CREB Binding Protein Signaling Attenuates House Dust Mite-Induced Goblet Cell Metaplasia in Mice

Excessive mucus production is a major feature of allergic asthma. Disruption of epithelial junctions by allergens such as house dust mite (HDM) results in the activation of β-catenin signaling, which has been reported to stimulate goblet cell differentiation. β-catenin interacts with various co-acti...

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Detalles Bibliográficos
Autores principales: Kuchibhotla, Virinchi N. S., Starkey, Malcolm R., Reid, Andrew T., Heijink, Irene H., Nawijn, Martijn C., Hansbro, Philip M., Knight, Darryl A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353457/
https://www.ncbi.nlm.nih.gov/pubmed/34385933
http://dx.doi.org/10.3389/fphys.2021.690531

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