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Generation of hypoxia-sensing chimeric antigen receptor T cells

Exploiting hypoxia in solid malignancies to restrict expression of chimeric antigen receptors (CARs) on engineered T cells to the tumor microenvironment overcomes the risk of on-target off-tumor toxicity and minimizes tonic signaling, which promotes CAR T cell exhaustion. This protocol summarizes th...

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Detalles Bibliográficos
Autores principales:	Kosti, Paris, Larios-Martinez, Karen I., Maher, John, Arnold, James N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353489/ https://www.ncbi.nlm.nih.gov/pubmed/34401788 http://dx.doi.org/10.1016/j.xpro.2021.100723

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