Correlation of Lipid Profile and Glycated Hemoglobin as a New Prognostic Criterion for Type 2 Diabetes Mellitus Development and Progression

The aim of the study was to assess correlations between the lipid profile and glycated hemoglobin in order to define their prognostic value as a criterion for the development and progression of type 2 diabetes mellitus (DM2) in individuals with metabolic syndrome and low body mass. MATERIALS AND METHODS: The study included the results of examining 50 patients with metabolic syndrome (group 1), 50 with low body mass index (BMI) (group 2), 50 with DM2 (group 3), and 50 apparently healthy people (control group). Biochemical indices of the lipid profile and glycated hemoglobin in the venous blood were assessed using analyzers Clima MC-15 (Spain), BS-200, and BS-200 E (China). RESULTS: It has been established that correlations of the parameters such as high-density lipoproteins (HDL), low-density lipoproteins (LDL), urea, and creatinine with BMI are expressed statistically more significantly in women in groups 1 and 2 in comparison with group 3, while in men the reverse situation is observed. Besides, correlation of triglyceride levels with BMI is statistically more marked in patients with DM2 than in apparently healthy people being positive in women and negative in men. Thus, HDL, LDL, creatinine, and urea may be diagnostically significant in the assessment of the development and progression of DM2 in men with metabolic syndrome since a strong positive correlation has been found between them and BMI, triglycerides were also found to be significant because a strong negative correlation has been detected between them and BMI. For women with metabolic syndrome, the combination of a weak correlation of BMI with the levels of HDL, LDL, urea, and creatinine and a strong positive correlation with triglycerides may be considered to be a prognostically significant index. CONCLUSION: New correlation characteristics of biochemical blood indices in DM2 may serve as prognostic criteria for disease development and progression.