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Sex differences between serum total bilirubin levels and cognition in patients with schizophrenia
BACKGROUND: Cognitive deficits are common in patients with schizophrenia (SCZ). Abnormal serum total bilirubin (TBIL) levels have been involved in cognitive deficits associated with neuropsychiatric diseases such as mild cognitive impairment and subcortical ischemic vascular disease. However, this r...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353745/ https://www.ncbi.nlm.nih.gov/pubmed/34376171 http://dx.doi.org/10.1186/s12888-021-03407-8 |
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author | He, Shen Li, Yange Li, Tian Xu, Feikang Zeng, Duan Shi, Yue Zhao, Nan Zhang, Lei Ma, Yin Zhu Wang, Qiang Yu, Wenjuan Shen, Yifeng Huang, Jingjing Li, Huafang |
author_facet | He, Shen Li, Yange Li, Tian Xu, Feikang Zeng, Duan Shi, Yue Zhao, Nan Zhang, Lei Ma, Yin Zhu Wang, Qiang Yu, Wenjuan Shen, Yifeng Huang, Jingjing Li, Huafang |
author_sort | He, Shen |
collection | PubMed |
description | BACKGROUND: Cognitive deficits are common in patients with schizophrenia (SCZ). Abnormal serum total bilirubin (TBIL) levels have been involved in cognitive deficits associated with neuropsychiatric diseases such as mild cognitive impairment and subcortical ischemic vascular disease. However, this relationship has not yet been fully investigated in patients with SCZ. Therefore, the aim of this study was to investigate the association between the serum TBIL concentration and cognitive deficits in SCZ patients and to determine whether a sex difference exists in the association. METHODS: A total of 455 participants were eligible and included in this cross-sectional study. Cognition was evaluated using the Montreal Cognitive Assessment. Serum TBIL concentration was measured with an automatic biochemistry analyzer according to the routine protocol in the hospital medical laboratory. RESULTS: Serum TBIL levels were lower in the cognition impairment group than in the cognition normal group in male patients. In contrast, serum TBIL levels tended to be increased in the cognition impairment group in female patients, although the difference was not significant. Further stepwise multiple regression analysis stratified by sex showed that serum TBIL was independently and positively associated with cognitive function in male patients but not in female patients. Moreover, the association between serum TBIL level and cognitive function was also identified by the propensity score matching (PSM) method in male patients, but not in female patients. CONCLUSION: These findings suggest that lower serum TBIL levels may be associated with cognitive impairment in male SCZ patients. |
format | Online Article Text |
id | pubmed-8353745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-83537452021-08-10 Sex differences between serum total bilirubin levels and cognition in patients with schizophrenia He, Shen Li, Yange Li, Tian Xu, Feikang Zeng, Duan Shi, Yue Zhao, Nan Zhang, Lei Ma, Yin Zhu Wang, Qiang Yu, Wenjuan Shen, Yifeng Huang, Jingjing Li, Huafang BMC Psychiatry Research BACKGROUND: Cognitive deficits are common in patients with schizophrenia (SCZ). Abnormal serum total bilirubin (TBIL) levels have been involved in cognitive deficits associated with neuropsychiatric diseases such as mild cognitive impairment and subcortical ischemic vascular disease. However, this relationship has not yet been fully investigated in patients with SCZ. Therefore, the aim of this study was to investigate the association between the serum TBIL concentration and cognitive deficits in SCZ patients and to determine whether a sex difference exists in the association. METHODS: A total of 455 participants were eligible and included in this cross-sectional study. Cognition was evaluated using the Montreal Cognitive Assessment. Serum TBIL concentration was measured with an automatic biochemistry analyzer according to the routine protocol in the hospital medical laboratory. RESULTS: Serum TBIL levels were lower in the cognition impairment group than in the cognition normal group in male patients. In contrast, serum TBIL levels tended to be increased in the cognition impairment group in female patients, although the difference was not significant. Further stepwise multiple regression analysis stratified by sex showed that serum TBIL was independently and positively associated with cognitive function in male patients but not in female patients. Moreover, the association between serum TBIL level and cognitive function was also identified by the propensity score matching (PSM) method in male patients, but not in female patients. CONCLUSION: These findings suggest that lower serum TBIL levels may be associated with cognitive impairment in male SCZ patients. BioMed Central 2021-08-10 /pmc/articles/PMC8353745/ /pubmed/34376171 http://dx.doi.org/10.1186/s12888-021-03407-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research He, Shen Li, Yange Li, Tian Xu, Feikang Zeng, Duan Shi, Yue Zhao, Nan Zhang, Lei Ma, Yin Zhu Wang, Qiang Yu, Wenjuan Shen, Yifeng Huang, Jingjing Li, Huafang Sex differences between serum total bilirubin levels and cognition in patients with schizophrenia |
title | Sex differences between serum total bilirubin levels and cognition in patients with schizophrenia |
title_full | Sex differences between serum total bilirubin levels and cognition in patients with schizophrenia |
title_fullStr | Sex differences between serum total bilirubin levels and cognition in patients with schizophrenia |
title_full_unstemmed | Sex differences between serum total bilirubin levels and cognition in patients with schizophrenia |
title_short | Sex differences between serum total bilirubin levels and cognition in patients with schizophrenia |
title_sort | sex differences between serum total bilirubin levels and cognition in patients with schizophrenia |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353745/ https://www.ncbi.nlm.nih.gov/pubmed/34376171 http://dx.doi.org/10.1186/s12888-021-03407-8 |
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