Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia–reperfusion

BACKGROUND: Celastrol (cel) was one of the earliest isolated and identified chemical constituents of Tripterygium wilfordii Hook. f. Based on a cel probe (cel-p) that maintained the bioactivity of the parent compound, the targets of cel in cerebral ischemia–reperfusion (I/R) injury were comprehensiv...

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Detalles Bibliográficos
Autores principales: Liu, Dan-Dan, Luo, Piao, Gu, Liwei, Zhang, Qian, Gao, Peng, Zhu, Yongping, Chen, Xiao, Guo, Qiuyan, Zhang, Junzhe, Ma, Nan, Wang, Jigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353826/
https://www.ncbi.nlm.nih.gov/pubmed/34372857
http://dx.doi.org/10.1186/s12974-021-02216-w

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