Recent advances of m(6)A methylation modification in esophageal squamous cell carcinoma

In recent years, with the development of RNA sequencing technology and bioinformatics methods, the epigenetic modification of RNA based on N(6)-methyladenosine (m(6)A) has gradually become a research hotspot in the field of bioscience. m(6)A is the most abundant internal modification in eukaryotic m...

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Autores principales: Zhang, Xiaoqing, Lu, Ning, Wang, Li, Wang, Yixuan, Li, Minna, Zhou, Ying, Cui, Manli, Zhang, Mingxin, Zhang, Lingmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353866/
https://www.ncbi.nlm.nih.gov/pubmed/34376206
http://dx.doi.org/10.1186/s12935-021-02132-2
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author Zhang, Xiaoqing
Lu, Ning
Wang, Li
Wang, Yixuan
Li, Minna
Zhou, Ying
Cui, Manli
Zhang, Mingxin
Zhang, Lingmin
author_facet Zhang, Xiaoqing
Lu, Ning
Wang, Li
Wang, Yixuan
Li, Minna
Zhou, Ying
Cui, Manli
Zhang, Mingxin
Zhang, Lingmin
author_sort Zhang, Xiaoqing
collection PubMed
description In recent years, with the development of RNA sequencing technology and bioinformatics methods, the epigenetic modification of RNA based on N(6)-methyladenosine (m(6)A) has gradually become a research hotspot in the field of bioscience. m(6)A is the most abundant internal modification in eukaryotic messenger RNAs (mRNAs). m(6)A methylation modification can dynamically and reversibly regulate RNA transport, localization, translation and degradation through the interaction of methyltransferase, demethylase and reading protein. m(6)A methylation can regulate the expression of proto-oncogenes and tumor suppressor genes at the epigenetic modification level to affect tumor occurrence and metastasis. The morbidity and mortality of esophageal cancer (EC) are still high worldwide. Esophageal squamous cell carcinoma (ESCC) is the most common tissue subtype of EC. This article reviews the related concepts, biological functions and recent advances of m(6)A methylation in ESCC, and looks forward to the prospect of m(6)A methylation as a new diagnostic biomarker and potential therapeutic target for ESCC.
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spelling pubmed-83538662021-08-11 Recent advances of m(6)A methylation modification in esophageal squamous cell carcinoma Zhang, Xiaoqing Lu, Ning Wang, Li Wang, Yixuan Li, Minna Zhou, Ying Cui, Manli Zhang, Mingxin Zhang, Lingmin Cancer Cell Int Review In recent years, with the development of RNA sequencing technology and bioinformatics methods, the epigenetic modification of RNA based on N(6)-methyladenosine (m(6)A) has gradually become a research hotspot in the field of bioscience. m(6)A is the most abundant internal modification in eukaryotic messenger RNAs (mRNAs). m(6)A methylation modification can dynamically and reversibly regulate RNA transport, localization, translation and degradation through the interaction of methyltransferase, demethylase and reading protein. m(6)A methylation can regulate the expression of proto-oncogenes and tumor suppressor genes at the epigenetic modification level to affect tumor occurrence and metastasis. The morbidity and mortality of esophageal cancer (EC) are still high worldwide. Esophageal squamous cell carcinoma (ESCC) is the most common tissue subtype of EC. This article reviews the related concepts, biological functions and recent advances of m(6)A methylation in ESCC, and looks forward to the prospect of m(6)A methylation as a new diagnostic biomarker and potential therapeutic target for ESCC. BioMed Central 2021-08-10 /pmc/articles/PMC8353866/ /pubmed/34376206 http://dx.doi.org/10.1186/s12935-021-02132-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Xiaoqing
Lu, Ning
Wang, Li
Wang, Yixuan
Li, Minna
Zhou, Ying
Cui, Manli
Zhang, Mingxin
Zhang, Lingmin
Recent advances of m(6)A methylation modification in esophageal squamous cell carcinoma
title Recent advances of m(6)A methylation modification in esophageal squamous cell carcinoma
title_full Recent advances of m(6)A methylation modification in esophageal squamous cell carcinoma
title_fullStr Recent advances of m(6)A methylation modification in esophageal squamous cell carcinoma
title_full_unstemmed Recent advances of m(6)A methylation modification in esophageal squamous cell carcinoma
title_short Recent advances of m(6)A methylation modification in esophageal squamous cell carcinoma
title_sort recent advances of m(6)a methylation modification in esophageal squamous cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353866/
https://www.ncbi.nlm.nih.gov/pubmed/34376206
http://dx.doi.org/10.1186/s12935-021-02132-2
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