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Phytochemical library screening reveals betulinic acid as a novel Skp2‐SCF E3 ligase inhibitor in non–small cell lung cancer

Skp2 is overexpressed in multiple cancers and plays a critical role in tumor development through ubiquitin/proteasome‐dependent degradation of its substrate proteins. Drugs targeting Skp2 have exhibited promising anticancer activity. Here, we identified a plant‐derived Skp2 inhibitor, betulinic acid...

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Detalles Bibliográficos
Autores principales:	He, Dan‐Hua, Chen, Yu‐Fei, Zhou, Yi‐Le, Zhang, Shi‐Bing, Hong, Ming, Yu, Xianjun, Wei, Su‐Fen, Fan, Xiang‐Zhen, Li, Si‐Yi, Wang, Qi, Lu, Yongzhi, Liu, Yong‐Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353894/ https://www.ncbi.nlm.nih.gov/pubmed/34080260 http://dx.doi.org/10.1111/cas.15005

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