Recombinant human plasma gelsolin (rhu-pGSN) in a patient hospitalized with critical COVID-19 pneumonia

Life-threatening COVID-19 pneumonia follows an exaggerated immune response to SARS-CoV-2. pGSN levels fall after SARS-CoV-2 infection. Rhu-pGSN improves outcomes in models of inflammation. In an intubated patient with critical COVID-19 pneumonia and progressive hypoxemia despite standard care, impro...

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Autores principales: Catteeuw, Julie V., DiNubile, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of British Infection Association. 2021
Materias:
Case Reports and Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353968/
https://www.ncbi.nlm.nih.gov/pubmed/34396087
http://dx.doi.org/10.1016/j.clinpr.2021.100088
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author Catteeuw, Julie V.
DiNubile, Mark J.
author_facet Catteeuw, Julie V.
DiNubile, Mark J.
author_sort Catteeuw, Julie V.
collection PubMed
description Life-threatening COVID-19 pneumonia follows an exaggerated immune response to SARS-CoV-2. pGSN levels fall after SARS-CoV-2 infection. Rhu-pGSN improves outcomes in models of inflammation. In an intubated patient with critical COVID-19 pneumonia and progressive hypoxemia despite standard care, improvement became evident during rhu-pGSN infusions with full recovery within a few weeks.
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spelling pubmed-83539682021-08-10 Recombinant human plasma gelsolin (rhu-pGSN) in a patient hospitalized with critical COVID-19 pneumonia Catteeuw, Julie V. DiNubile, Mark J. Clin Infect Pract Case Reports and Series Life-threatening COVID-19 pneumonia follows an exaggerated immune response to SARS-CoV-2. pGSN levels fall after SARS-CoV-2 infection. Rhu-pGSN improves outcomes in models of inflammation. In an intubated patient with critical COVID-19 pneumonia and progressive hypoxemia despite standard care, improvement became evident during rhu-pGSN infusions with full recovery within a few weeks. The Authors. Published by Elsevier Ltd on behalf of British Infection Association. 2021-11 2021-08-10 /pmc/articles/PMC8353968/ /pubmed/34396087 http://dx.doi.org/10.1016/j.clinpr.2021.100088 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Reports and Series
Catteeuw, Julie V.
DiNubile, Mark J.
Recombinant human plasma gelsolin (rhu-pGSN) in a patient hospitalized with critical COVID-19 pneumonia
title Recombinant human plasma gelsolin (rhu-pGSN) in a patient hospitalized with critical COVID-19 pneumonia
title_full Recombinant human plasma gelsolin (rhu-pGSN) in a patient hospitalized with critical COVID-19 pneumonia
title_fullStr Recombinant human plasma gelsolin (rhu-pGSN) in a patient hospitalized with critical COVID-19 pneumonia
title_full_unstemmed Recombinant human plasma gelsolin (rhu-pGSN) in a patient hospitalized with critical COVID-19 pneumonia
title_short Recombinant human plasma gelsolin (rhu-pGSN) in a patient hospitalized with critical COVID-19 pneumonia
title_sort recombinant human plasma gelsolin (rhu-pgsn) in a patient hospitalized with critical covid-19 pneumonia
topic Case Reports and Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353968/
https://www.ncbi.nlm.nih.gov/pubmed/34396087
http://dx.doi.org/10.1016/j.clinpr.2021.100088
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