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CCL2: An Important Mediator Between Tumor Cells and Host Cells in Tumor Microenvironment
Tumor microenvironment (TME) formation is a major cause of immunosuppression. The TME consists of a considerable number of macrophages and stromal cells that have been identified in multiple tumor types. CCL2 is the strongest chemoattractant involved in macrophage recruitment and a powerful initiato...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354025/ https://www.ncbi.nlm.nih.gov/pubmed/34386431 http://dx.doi.org/10.3389/fonc.2021.722916 |
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author | Jin, Jiakang Lin, Jinti Xu, Ankai Lou, Jianan Qian, Chao Li, Xiumao Wang, Yitian Yu, Wei Tao, Huimin |
author_facet | Jin, Jiakang Lin, Jinti Xu, Ankai Lou, Jianan Qian, Chao Li, Xiumao Wang, Yitian Yu, Wei Tao, Huimin |
author_sort | Jin, Jiakang |
collection | PubMed |
description | Tumor microenvironment (TME) formation is a major cause of immunosuppression. The TME consists of a considerable number of macrophages and stromal cells that have been identified in multiple tumor types. CCL2 is the strongest chemoattractant involved in macrophage recruitment and a powerful initiator of inflammation. Evidence indicates that CCL2 can attract other host cells in the TME and direct their differentiation in cooperation with other cytokines. Overall, CCL2 has an unfavorable effect on prognosis in tumor patients because of the accumulation of immunosuppressive cell subtypes. However, there is also evidence demonstrating that CCL2 enhances the anti-tumor capability of specific cell types such as inflammatory monocytes and neutrophils. The inflammation state of the tumor seems to have a bi-lateral role in tumor progression. Here, we review works focusing on the interactions between cancer cells and host cells, and on the biological role of CCL2 in these processes. |
format | Online Article Text |
id | pubmed-8354025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83540252021-08-11 CCL2: An Important Mediator Between Tumor Cells and Host Cells in Tumor Microenvironment Jin, Jiakang Lin, Jinti Xu, Ankai Lou, Jianan Qian, Chao Li, Xiumao Wang, Yitian Yu, Wei Tao, Huimin Front Oncol Oncology Tumor microenvironment (TME) formation is a major cause of immunosuppression. The TME consists of a considerable number of macrophages and stromal cells that have been identified in multiple tumor types. CCL2 is the strongest chemoattractant involved in macrophage recruitment and a powerful initiator of inflammation. Evidence indicates that CCL2 can attract other host cells in the TME and direct their differentiation in cooperation with other cytokines. Overall, CCL2 has an unfavorable effect on prognosis in tumor patients because of the accumulation of immunosuppressive cell subtypes. However, there is also evidence demonstrating that CCL2 enhances the anti-tumor capability of specific cell types such as inflammatory monocytes and neutrophils. The inflammation state of the tumor seems to have a bi-lateral role in tumor progression. Here, we review works focusing on the interactions between cancer cells and host cells, and on the biological role of CCL2 in these processes. Frontiers Media S.A. 2021-07-27 /pmc/articles/PMC8354025/ /pubmed/34386431 http://dx.doi.org/10.3389/fonc.2021.722916 Text en Copyright © 2021 Jin, Lin, Xu, Lou, Qian, Li, Wang, Yu and Tao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Jin, Jiakang Lin, Jinti Xu, Ankai Lou, Jianan Qian, Chao Li, Xiumao Wang, Yitian Yu, Wei Tao, Huimin CCL2: An Important Mediator Between Tumor Cells and Host Cells in Tumor Microenvironment |
title | CCL2: An Important Mediator Between Tumor Cells and Host Cells in Tumor Microenvironment |
title_full | CCL2: An Important Mediator Between Tumor Cells and Host Cells in Tumor Microenvironment |
title_fullStr | CCL2: An Important Mediator Between Tumor Cells and Host Cells in Tumor Microenvironment |
title_full_unstemmed | CCL2: An Important Mediator Between Tumor Cells and Host Cells in Tumor Microenvironment |
title_short | CCL2: An Important Mediator Between Tumor Cells and Host Cells in Tumor Microenvironment |
title_sort | ccl2: an important mediator between tumor cells and host cells in tumor microenvironment |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354025/ https://www.ncbi.nlm.nih.gov/pubmed/34386431 http://dx.doi.org/10.3389/fonc.2021.722916 |
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