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Case Report: Rare Case of Synchronous Neck Metastasis From Metachronous Bilateral Renal Cell Carcinoma

Renal cell carcinoma (RCC) is a malignant tumor that can metastasize easily. Hence, many patients have already developed metastasis when they are diagnosed. It is also one of the most common tumors that metastasize to the head and neck through extranodal disease. Herein, we reported a case of a 53-y...

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Autores principales: Dai, Jun, Fang, Chen, Yang, Xiaoqun, Huang, Xin, He, Wei, Wang, Chenghe, Zhao, Juping, Sun, Fukang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354027/
https://www.ncbi.nlm.nih.gov/pubmed/34386420
http://dx.doi.org/10.3389/fonc.2021.677714
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author Dai, Jun
Fang, Chen
Yang, Xiaoqun
Huang, Xin
He, Wei
Wang, Chenghe
Zhao, Juping
Sun, Fukang
author_facet Dai, Jun
Fang, Chen
Yang, Xiaoqun
Huang, Xin
He, Wei
Wang, Chenghe
Zhao, Juping
Sun, Fukang
author_sort Dai, Jun
collection PubMed
description Renal cell carcinoma (RCC) is a malignant tumor that can metastasize easily. Hence, many patients have already developed metastasis when they are diagnosed. It is also one of the most common tumors that metastasize to the head and neck through extranodal disease. Herein, we reported a case of a 53-year-old man with cervical metastasis from bilateral RCC. Interestingly, whole exome sequencing (WES) and clonal evolution analysis revealed that bilateral renal tumor lesions and neck metastases (squamous cell carcinoma) share the same subclones and a large number of gene variants, while the pathological morphology is different (left nephrotic foci, a mixed pattern of mucinous tubular and spindle cell carcinoma (MTSCC) with papillary adenoma; right renal foci, papillary renal cell carcinoma (PRCC)). This was first reported in RCCs to the best of our knowledge. This case suggests that genotype analysis can be a powerful supplementary examination for clinical histopathological diagnosis. Gene detection has great significance for the accurate diagnosis and treatment of RCC metastasis or multiple lesions.
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spelling pubmed-83540272021-08-11 Case Report: Rare Case of Synchronous Neck Metastasis From Metachronous Bilateral Renal Cell Carcinoma Dai, Jun Fang, Chen Yang, Xiaoqun Huang, Xin He, Wei Wang, Chenghe Zhao, Juping Sun, Fukang Front Oncol Oncology Renal cell carcinoma (RCC) is a malignant tumor that can metastasize easily. Hence, many patients have already developed metastasis when they are diagnosed. It is also one of the most common tumors that metastasize to the head and neck through extranodal disease. Herein, we reported a case of a 53-year-old man with cervical metastasis from bilateral RCC. Interestingly, whole exome sequencing (WES) and clonal evolution analysis revealed that bilateral renal tumor lesions and neck metastases (squamous cell carcinoma) share the same subclones and a large number of gene variants, while the pathological morphology is different (left nephrotic foci, a mixed pattern of mucinous tubular and spindle cell carcinoma (MTSCC) with papillary adenoma; right renal foci, papillary renal cell carcinoma (PRCC)). This was first reported in RCCs to the best of our knowledge. This case suggests that genotype analysis can be a powerful supplementary examination for clinical histopathological diagnosis. Gene detection has great significance for the accurate diagnosis and treatment of RCC metastasis or multiple lesions. Frontiers Media S.A. 2021-07-27 /pmc/articles/PMC8354027/ /pubmed/34386420 http://dx.doi.org/10.3389/fonc.2021.677714 Text en Copyright © 2021 Dai, Fang, Yang, Huang, He, Wang, Zhao and Sun https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Dai, Jun
Fang, Chen
Yang, Xiaoqun
Huang, Xin
He, Wei
Wang, Chenghe
Zhao, Juping
Sun, Fukang
Case Report: Rare Case of Synchronous Neck Metastasis From Metachronous Bilateral Renal Cell Carcinoma
title Case Report: Rare Case of Synchronous Neck Metastasis From Metachronous Bilateral Renal Cell Carcinoma
title_full Case Report: Rare Case of Synchronous Neck Metastasis From Metachronous Bilateral Renal Cell Carcinoma
title_fullStr Case Report: Rare Case of Synchronous Neck Metastasis From Metachronous Bilateral Renal Cell Carcinoma
title_full_unstemmed Case Report: Rare Case of Synchronous Neck Metastasis From Metachronous Bilateral Renal Cell Carcinoma
title_short Case Report: Rare Case of Synchronous Neck Metastasis From Metachronous Bilateral Renal Cell Carcinoma
title_sort case report: rare case of synchronous neck metastasis from metachronous bilateral renal cell carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354027/
https://www.ncbi.nlm.nih.gov/pubmed/34386420
http://dx.doi.org/10.3389/fonc.2021.677714
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