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Movement Disorders and Liver Disease

The association of movement disorders with structural or functional hepatic disease occurs in three principal scenarios: (1) combined involvement of both organ systems from a single disease entity, (2) nervous system dysfunction resulting from exposure to toxic compounds in the setting of defective...

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Autores principales: Mulroy, Eoin, Baschieri, Francesca, Magrinelli, Francesca, Latorre, Anna, Cortelli, Pietro, Bhatia, Kailash P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354085/
https://www.ncbi.nlm.nih.gov/pubmed/34401403
http://dx.doi.org/10.1002/mdc3.13238
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author Mulroy, Eoin
Baschieri, Francesca
Magrinelli, Francesca
Latorre, Anna
Cortelli, Pietro
Bhatia, Kailash P.
author_facet Mulroy, Eoin
Baschieri, Francesca
Magrinelli, Francesca
Latorre, Anna
Cortelli, Pietro
Bhatia, Kailash P.
author_sort Mulroy, Eoin
collection PubMed
description The association of movement disorders with structural or functional hepatic disease occurs in three principal scenarios: (1) combined involvement of both organ systems from a single disease entity, (2) nervous system dysfunction resulting from exposure to toxic compounds in the setting of defective hepatic clearance, or (3) hepatic and/or neurological injury secondary to exposure to exogenous drugs or toxins. An important early step in the workup of any patient with combined movement disorders and liver disease is the exclusion of Wilson's disease. Diagnostic delay remains common for this treatable disorder, and this has major implications for patient outcomes. Thereafter, a structured approach integrating variables such as age of onset, tempo of progression, nature and severity of liver involvement, movement disorder phenomenology, exposure to drugs/toxins and laboratory/neuroimaging findings is key to ensuring timely diagnosis and disease‐specific therapy. Herein, we provide an overview of disorders which may manifest with a combination of movement disorders and liver disease, structured under the three headings as detailed above. In each section, the most common disorders are discussed, along with important clinical pearls, suggested diagnostic workup, differential diagnoses and where appropriate, treatment considerations.
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spelling pubmed-83540852021-08-15 Movement Disorders and Liver Disease Mulroy, Eoin Baschieri, Francesca Magrinelli, Francesca Latorre, Anna Cortelli, Pietro Bhatia, Kailash P. Mov Disord Clin Pract Reviews The association of movement disorders with structural or functional hepatic disease occurs in three principal scenarios: (1) combined involvement of both organ systems from a single disease entity, (2) nervous system dysfunction resulting from exposure to toxic compounds in the setting of defective hepatic clearance, or (3) hepatic and/or neurological injury secondary to exposure to exogenous drugs or toxins. An important early step in the workup of any patient with combined movement disorders and liver disease is the exclusion of Wilson's disease. Diagnostic delay remains common for this treatable disorder, and this has major implications for patient outcomes. Thereafter, a structured approach integrating variables such as age of onset, tempo of progression, nature and severity of liver involvement, movement disorder phenomenology, exposure to drugs/toxins and laboratory/neuroimaging findings is key to ensuring timely diagnosis and disease‐specific therapy. Herein, we provide an overview of disorders which may manifest with a combination of movement disorders and liver disease, structured under the three headings as detailed above. In each section, the most common disorders are discussed, along with important clinical pearls, suggested diagnostic workup, differential diagnoses and where appropriate, treatment considerations. John Wiley & Sons, Inc. 2021-05-31 /pmc/articles/PMC8354085/ /pubmed/34401403 http://dx.doi.org/10.1002/mdc3.13238 Text en © 2021 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals LLC. on behalf of International Parkinson and Movement Disorder Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Mulroy, Eoin
Baschieri, Francesca
Magrinelli, Francesca
Latorre, Anna
Cortelli, Pietro
Bhatia, Kailash P.
Movement Disorders and Liver Disease
title Movement Disorders and Liver Disease
title_full Movement Disorders and Liver Disease
title_fullStr Movement Disorders and Liver Disease
title_full_unstemmed Movement Disorders and Liver Disease
title_short Movement Disorders and Liver Disease
title_sort movement disorders and liver disease
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354085/
https://www.ncbi.nlm.nih.gov/pubmed/34401403
http://dx.doi.org/10.1002/mdc3.13238
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