Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system

The retina, as part of the central nervous system is an ideal model to study the response of neurons to injury and disease and to test new treatments. During the last decade is becoming clear that unilateral lesions in bilateral areas of the central nervous system trigger an inflammatory response in...

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Autores principales: Lucas-Ruiz, Fernando, Galindo-Romero, Caridad, Albaladejo-García, Virginia, Vidal-Sanz, Manuel, Agudo-Barriuso, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354113/
https://www.ncbi.nlm.nih.gov/pubmed/33818483
http://dx.doi.org/10.4103/1673-5374.310670
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author Lucas-Ruiz, Fernando
Galindo-Romero, Caridad
Albaladejo-García, Virginia
Vidal-Sanz, Manuel
Agudo-Barriuso, Marta
author_facet Lucas-Ruiz, Fernando
Galindo-Romero, Caridad
Albaladejo-García, Virginia
Vidal-Sanz, Manuel
Agudo-Barriuso, Marta
author_sort Lucas-Ruiz, Fernando
collection PubMed
description The retina, as part of the central nervous system is an ideal model to study the response of neurons to injury and disease and to test new treatments. During the last decade is becoming clear that unilateral lesions in bilateral areas of the central nervous system trigger an inflammatory response in the contralateral uninjured site. This effect has been better studied in the visual system where, as a rule, one retina is used as experimental and the other as control. Contralateral retinas in unilateral models of retinal injury show neuronal degeneration and glial activation. The mechanisms by which this adverse response in the central nervous system occurs are discussed in this review, focusing primarily on the visual system.
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spelling pubmed-83541132021-08-23 Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system Lucas-Ruiz, Fernando Galindo-Romero, Caridad Albaladejo-García, Virginia Vidal-Sanz, Manuel Agudo-Barriuso, Marta Neural Regen Res Review The retina, as part of the central nervous system is an ideal model to study the response of neurons to injury and disease and to test new treatments. During the last decade is becoming clear that unilateral lesions in bilateral areas of the central nervous system trigger an inflammatory response in the contralateral uninjured site. This effect has been better studied in the visual system where, as a rule, one retina is used as experimental and the other as control. Contralateral retinas in unilateral models of retinal injury show neuronal degeneration and glial activation. The mechanisms by which this adverse response in the central nervous system occurs are discussed in this review, focusing primarily on the visual system. Wolters Kluwer - Medknow 2021-03-25 /pmc/articles/PMC8354113/ /pubmed/33818483 http://dx.doi.org/10.4103/1673-5374.310670 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Lucas-Ruiz, Fernando
Galindo-Romero, Caridad
Albaladejo-García, Virginia
Vidal-Sanz, Manuel
Agudo-Barriuso, Marta
Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system
title Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system
title_full Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system
title_fullStr Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system
title_full_unstemmed Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system
title_short Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system
title_sort mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354113/
https://www.ncbi.nlm.nih.gov/pubmed/33818483
http://dx.doi.org/10.4103/1673-5374.310670
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