Antibody-Based Inhibition of Pathogenic New World Hemorrhagic Fever Mammarenaviruses by Steric Occlusion of the Human Transferrin Receptor 1 Apical Domain

Pathogenic clade B New World mammarenaviruses (NWM) can cause Argentine, Venezuelan, Brazilian, and Bolivian hemorrhagic fevers. Sequence variability among NWM glycoproteins (GP) poses a challenge to the development of broadly neutralizing therapeutics against the entire clade of viruses. However, b...

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Detalles Bibliográficos
Autores principales: Ferrero, Sol, Flores, Maria D., Short, Connor, Vazquez, Cecilia A., Clark, Lars E., Ziegenbein, James, Zink, Samantha, Fuentes, Daniel, Payes, Cristian, Batto, María V., Collazo, Michael, García, Cybele C., Abraham, Jonathan, Cordo, Sandra M., Rodriguez, Jose A., Helguera, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Structure and Assembly
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354235/
https://www.ncbi.nlm.nih.gov/pubmed/34132574
http://dx.doi.org/10.1128/JVI.01868-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354235/
https://www.ncbi.nlm.nih.gov/pubmed/34132574
http://dx.doi.org/10.1128/JVI.01868-20

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