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PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8(+)T cells and promoting fatty acid metabolism

BACKGROUND: The phosphatidylinositol 3-kinase (PI3K) is frequently hyperactivated in cancer and plays important roles in both malignant and immune cells. The effect of PI3Kα inhibitors on the tumor microenvironment (TME) remains largely unknown. Here, we investigated the modulation of the TME by a c...

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Detalles Bibliográficos
Autores principales:	Sun, Pu, Zhang, Xi, Wang, Rong-Jing, Ma, Qing-Yang, Xu, Lan, Wang, Yi, Liao, Hui-Ping, Wang, Hai-Long, Hu, Lan-Dian, Kong, Xiangyin, Ding, Jian, Meng, Ling-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354295/ https://www.ncbi.nlm.nih.gov/pubmed/34373258 http://dx.doi.org/10.1136/jitc-2021-003093

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