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All‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort

We aimed to determine mortality risk in underweight patients with diabetic nephropathy for microalbuminuria or macroalbuminuria. We analyzed mortality and death‐cause data from BioBank Japan, with baseline years 2003–2007. We analyzed mortality rates from all causes and ischemic heart disease, accor...

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Autores principales: Yokomichi, Hiroshi, Mochizuki, Mie, Hirata, Makoto, Nagai, Akiko, Kojima, Reiji, Horiuchi, Sayaka, Ooka, Tadao, Akiyama, Yuka, Shinohara, Ryoji, Miyake, Kunio, Yamagata, Zentaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354489/
https://www.ncbi.nlm.nih.gov/pubmed/33340268
http://dx.doi.org/10.1111/jdi.13483
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author Yokomichi, Hiroshi
Mochizuki, Mie
Hirata, Makoto
Nagai, Akiko
Kojima, Reiji
Horiuchi, Sayaka
Ooka, Tadao
Akiyama, Yuka
Shinohara, Ryoji
Miyake, Kunio
Yamagata, Zentaro
author_facet Yokomichi, Hiroshi
Mochizuki, Mie
Hirata, Makoto
Nagai, Akiko
Kojima, Reiji
Horiuchi, Sayaka
Ooka, Tadao
Akiyama, Yuka
Shinohara, Ryoji
Miyake, Kunio
Yamagata, Zentaro
author_sort Yokomichi, Hiroshi
collection PubMed
description We aimed to determine mortality risk in underweight patients with diabetic nephropathy for microalbuminuria or macroalbuminuria. We analyzed mortality and death‐cause data from BioBank Japan, with baseline years 2003–2007. We analyzed mortality rates from all causes and ischemic heart disease, according to body mass index (<18.5, 18.5–21.9, 22–24.9 and ≥25 kg/m(2)). The mean (standard deviation) of patient age, body mass index, and glycated hemoglobin at enrollment was 61.6 years (11.7 years), 25.0 kg/m(2) (4.4 kg/m(2)) and 7.7% (1.5%), respectively. Hazard ratios of all‐cause and ischemic heart disease mortality were highest (1.79 [P = 0.0001] and 2.95 [P = 0.027], respectively) in patients with body mass index <18.5 kg/m(2), as compared with body mass index 22–24.9 kg/m(2). All‐cause mortality risk for body mass index <18.5 kg/m(2) was similar to that for current smokers (hazard ratio 1.70, P < 0.0001). Underweight could be a predictor of mortality risk in patients with diabetic nephropathy for microalbuminuria or macroalbuminuria.
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spelling pubmed-83544892021-08-15 All‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort Yokomichi, Hiroshi Mochizuki, Mie Hirata, Makoto Nagai, Akiko Kojima, Reiji Horiuchi, Sayaka Ooka, Tadao Akiyama, Yuka Shinohara, Ryoji Miyake, Kunio Yamagata, Zentaro J Diabetes Investig Articles We aimed to determine mortality risk in underweight patients with diabetic nephropathy for microalbuminuria or macroalbuminuria. We analyzed mortality and death‐cause data from BioBank Japan, with baseline years 2003–2007. We analyzed mortality rates from all causes and ischemic heart disease, according to body mass index (<18.5, 18.5–21.9, 22–24.9 and ≥25 kg/m(2)). The mean (standard deviation) of patient age, body mass index, and glycated hemoglobin at enrollment was 61.6 years (11.7 years), 25.0 kg/m(2) (4.4 kg/m(2)) and 7.7% (1.5%), respectively. Hazard ratios of all‐cause and ischemic heart disease mortality were highest (1.79 [P = 0.0001] and 2.95 [P = 0.027], respectively) in patients with body mass index <18.5 kg/m(2), as compared with body mass index 22–24.9 kg/m(2). All‐cause mortality risk for body mass index <18.5 kg/m(2) was similar to that for current smokers (hazard ratio 1.70, P < 0.0001). Underweight could be a predictor of mortality risk in patients with diabetic nephropathy for microalbuminuria or macroalbuminuria. John Wiley and Sons Inc. 2021-01-18 2021-08 /pmc/articles/PMC8354489/ /pubmed/33340268 http://dx.doi.org/10.1111/jdi.13483 Text en © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Articles
Yokomichi, Hiroshi
Mochizuki, Mie
Hirata, Makoto
Nagai, Akiko
Kojima, Reiji
Horiuchi, Sayaka
Ooka, Tadao
Akiyama, Yuka
Shinohara, Ryoji
Miyake, Kunio
Yamagata, Zentaro
All‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort
title All‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort
title_full All‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort
title_fullStr All‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort
title_full_unstemmed All‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort
title_short All‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort
title_sort all‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: biobank japan cohort
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354489/
https://www.ncbi.nlm.nih.gov/pubmed/33340268
http://dx.doi.org/10.1111/jdi.13483
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